LEMD3 抗体 (AA 535-852)
-
- 抗原 See all LEMD3 抗体
- LEMD3 (LEM Domain Containing 3 (LEMD3))
-
抗原表位
- AA 535-852
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This LEMD3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Flow Cytometry (FACS), ELISA
- 原理
- Anti-LEMD3 Antibody Picoband®
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
- Anti-LEMD3 Antibody Picoband® (ABIN7601987). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human LEMD3 recombinant protein (Position: H535-H852).
- 亚型
- IgG
- Top Product
- Discover our top product LEMD3 Primary Antibody
-
anti-LEM Domain Containing 3 (LEMD3) antibody
LEMD3 适用: 人, 猴, 犬 WB, IF, FACS, IHC, IHC (p) 宿主: 小鼠 Monoclonal 6C10 unconjugated
anti-LEM Domain Containing 3 (LEMD3) antibodyLEMD3 适用: 人, 猴, 犬, 大鼠 WB, IF, FACS 宿主: 小鼠 Monoclonal 3H1 unconjugated
-
- 应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Butkus, C. E., Michels, V. V., Lindor, N. M., Cooney, W. P., III. Melorheostosis in a patient with familial osteopoikilosis. Am. J. Med. Genet. 72: 43-46, 1997. 2. Debeer, P., Pykels, E., Lammens, J., Devriendt, K., Fryns, J.-P. Melorheostosis in a family with autosomal dominant osteopoikilosis: report of a third family. Am. J. Med. Genet. 119A: 188-193, 2003. 3. Hellemans, J., Preobrazhenska, O., Willaert, A., Debeer, P., Verdonk, P. C. M., Costa, T., Janssens, K., Menten, B., Van Roy, N., Vermeulen, S. J. T., Savarirayan, R., Van Hul, W., and 9 others. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nature Genet. 36: 1213-1218, 2004. - 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
- 抗原
- LEMD3 (LEM Domain Containing 3 (LEMD3))
- 别名
- LEMD3 (LEMD3 产品)
- 背景
-
Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Tissue Specificity: Expressed in all tissues.
Background: LEM domain-containing protein 3 (LEMD3), also known as MAN1, is an integral protein in the inner nuclear membrane (INM) of the nuclear envelope. It is encoded by the LEMD3 gene[5] and was first identified after it was isolated from the serum of a patient with a collagen vascular disease. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.
- 分子量
- 120 kDa
- 基因ID
- 23592
- UniProt
- Q9Y2U8
-
