LEMD3 抗体 (AA 535-852)
Quick Overview for LEMD3 抗体 (AA 535-852) (ABIN7601987)
抗原
See all LEMD3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 535-852
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原理
- Anti-LEMD3 Antibody Picoband®
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交叉反应 （详细）
- No cross reactivity with other proteins.
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产品特性
- Anti-LEMD3 Antibody Picoband® (ABIN7601987). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human LEMD3 recombinant protein (Position: H535-H852).
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亚型
- IgG
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anti-LEM Domain Containing 3 (LEMD3) antibody
LEMD3 适用: 人, 猴, 犬 WB, IF, FACS, IHC, IHC (p) 宿主: 小鼠 Monoclonal 6C10 unconjugated
anti-LEM Domain Containing 3 (LEMD3) antibodyLEMD3 适用: 人, 猴, 犬, 大鼠 WB, IF, FACS 宿主: 小鼠 Monoclonal 3H1 unconjugated
anti-LEM Domain Containing 3 (LEMD3) antibodyLEMD3 适用: 人 WB, IF, FACS, IHC, IP 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-LEM Domain Containing 3 (LEMD3) antibodyLEMD3 适用: 人, 猴, 犬 WB, IF, IP 宿主: 小鼠 Monoclonal 3H2 unconjugated
anti-LEM Domain Containing 3 (LEMD3) (C-Term) antibodyLEMD3 适用: 人, 小鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Butkus, C. E., Michels, V. V., Lindor, N. M., Cooney, W. P., III. Melorheostosis in a patient with familial osteopoikilosis. Am. J. Med. Genet. 72: 43-46, 1997. 2. Debeer, P., Pykels, E., Lammens, J., Devriendt, K., Fryns, J.-P. Melorheostosis in a family with autosomal dominant osteopoikilosis: report of a third family. Am. J. Med. Genet. 119A: 188-193, 2003. 3. Hellemans, J., Preobrazhenska, O., Willaert, A., Debeer, P., Verdonk, P. C. M., Costa, T., Janssens, K., Menten, B., Van Roy, N., Vermeulen, S. J. T., Savarirayan, R., Van Hul, W., and 9 others. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nature Genet. 36: 1213-1218, 2004. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- LEMD3 (LEM Domain Containing 3 (LEMD3))
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别名
- LEMD3
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背景
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Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Tissue Specificity: Expressed in all tissues.
Background: LEM domain-containing protein 3 (LEMD3), also known as MAN1, is an integral protein in the inner nuclear membrane (INM) of the nuclear envelope. It is encoded by the LEMD3 gene[5] and was first identified after it was isolated from the serum of a patient with a collagen vascular disease. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.
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分子量
- 120 kDa
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基因ID
- 23592
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UniProt
- Q9Y2U8
抗原
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