CA12 抗体 (AA 45-298)
Quick Overview for CA12 抗体 (AA 45-298) (ABIN7601765)
抗原
See all CA12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 45-298
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原理
- Anti-CA12 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CA12 Antibody Picoband® (ABIN7601765). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CA12 recombinant protein (Position: K45-A298).
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亚型
- IgG
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anti-Carbonic Anhydrase 12 (CA12) (AA 154-307) antibody
CA12 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Carbonic Anhydrase 12 (CA12) antibodyCA12 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-Carbonic Anhydrase 12 (CA12) antibodyCA12 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C6 unconjugated
anti-Carbonic Anhydrase 12 (CA12) (AA 25-124) antibodyCA12 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1D4 unconjugated
anti-Carbonic Anhydrase 12 (CA12) (AA 161-318) antibodyCA12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Carbonic Anhydrase 12 (CA12) (AA 25-301) antibodyCA12 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbonic Anhydrase 12 (CA12) (AA 1-354) antibodyCA12 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Carbonic Anhydrase 12 (CA12) antibodyCA12 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 4D1 unconjugated
anti-Carbonic Anhydrase 12 (CA12) (AA 241-340) antibodyCA12 适用: 人 ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Carbonic Anhydrase 12 (CA12) (AA 188-199) antibodyVerified CA12 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
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"Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
"1. Hong, JH, Muhammad, E, Zheng, C, Hershkovitz, E, Alkrinawi, S, Loewenthal, N, Parvari, R, Muallem, S (15 December 2015). "Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation". The Journal of Physiology. 593 (24): 5299-312. 2. Lee, M, Vecchio-Pagán, B, Sharma, N, Waheed, A, Li, X, Raraigh, KS, Robbins, S, Han, ST, Franca, AL, Pellicore, MJ, Evans, TA, Arcara, KM, Nguyen, H, Luan, S, Belchis, D, Hertecant, J, Zabner, J, Sly, WS, Cutting, GR (23 February 2016). "Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease". Human Molecular Genetics. 25 (10): 1923-1933. 3. Almståhl, A, Wikström, M (May 2003). "Electrolytes in stimulated whole saliva in individuals with hyposalivation of different origins". Archives of Oral Biology. 48 (5): 337-44. doi:10.1016/s0003-9969(02)00200-5. PMID 12711377. Manokaran, S, Zhang, X, Chen, W, Srivastava, DK (June 2010). "Differential modulation of the active site environment of human carbonic anhydrase XII by cationic quantum dots and polylysine". Biochimica et Biophysica Acta. 1804 (6): 1376-84. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CA12 (Carbonic Anhydrase 12 (CA12))
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别名
- CA12
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背景
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Synonyms: Carbonic anhydrase 12, Carbonate dehydratase XII, Carbonic anhydrase XII, CA-XII, Tumor antigen HOM-RCC-3.1.3, CA12
Tissue Specificity: Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat glands and bronchiolar epithelium (PubMed:26911677).
Background: Carbonic anhydrase 12 is an enzyme that in humans is encoded by the CA12 gene. It is mapped to 15q22.2. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10 % of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene.
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分子量
- 45 kDa
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基因ID
- 771
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UniProt
- O43570
抗原
-
