抗原 See all PLCE1 抗体: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))
抗原表位: AA 4-735
适用 2 2 1: 人
宿主 4: 兔
Compatible Secondaries
克隆类型 4: 多克隆
标记 4: This PLCE1 antibody is un-conjugated
应用范围 3 3 2 2 1 1: Western Blotting (WB), ELISA
原理: Anti-PLCE1 Antibody Picoband®
产品特性: Anti-PLCE1 Antibody Picoband® (ABIN7601632). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
纯化方法: Immunogen affinity purified.
免疫原: E.coli-derived human PLCE1 recombinant protein (Position: E4-E735). Human PLCE1 shares 74.6% and 73.6% amino acid (aa) sequence identity with mouse and rat PLCE1, respectively.
Top Product: Discover our top product PLCE1 Primary Antibody

anti-Phospholipase C, epsilon 1 (PLCE1) (AA 1-250) antibody

PLCE1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Phospholipase C, epsilon 1 (PLCE1) (AA 1-250) antibody

PLCE1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Phospholipase C, epsilon 1 (PLCE1) antibody

PLCE1 适用: 小鼠, 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Phospholipase C, epsilon 1 (PLCE1) antibody

PLCE1 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Boyer, O., Benoit, G., Gribouval, O., Nevo, F., Pawtowski, A., Bilge, I., Bircan, Z., Deschenes, G., Guay-Woodford, L. M., Hall, M., Macher, M.-A., Soulami, K., Stefanidis, C. J., Weiss, R., Loirat, C., Gubler, M.-C., Antignac, C. Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome. J. Med. Genet. 47: 445-452, 2010. 2. Bunney, T. D., Harris, R., Lamuno Gandarillas, N., Josephs, M. B., Roe, S. M., Sorli, S. C., Paterson, H. F., Rodrigues-Lima, F., Esposito, D., Ponting, C. P., Gierschik, P., Pearl, L. H., Driscoll, P. C., Katan, M. Structural and mechanistic insights into Ras association domains of phospholipase C epsilon. Molec. Cell 21: 495-507, 2006. 3. Evellin, S., Nolte, J., Tysack, K., vom Dorp, F., Thiel, M., Oude Weernink, P. A., Jakobs, K. H., Webb, E. J., Lomasney, J. W., Schmidt, M. Stimulation of phospholipase C-epsilon by the M(3) muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. J. Biol. Chem. 277: 16805-16813, 2002.
限制: 仅限研究用

状态: Lyophilized
溶解方式: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
浓度: 500 μg/mL
缓冲液: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
储存条件: 4 °C,-20 °C
储存方法: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

抗原: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))
别名: PLCE1 (PLCE1 产品)
背景: Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
分子量: 290 kDa
基因ID: 51196
UniProt: Q9P212
途径: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling

PLCE1 抗体 (AA 4-735)

PLCE1抗体详情