PLCE1 抗体
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北京 101111
Quick Overview for PLCE1 抗体 (ABIN7230680)
抗原
See all PLCE1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit Anti-PLCE1 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of PLCE1 protein
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from part region of human PLCE1 protein
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亚型
- IgG
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anti-Phospholipase C, epsilon 1 (PLCE1) (AA 1-250) antibody
PLCE1 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C, epsilon 1 (PLCE1) (AA 1-250) antibodyPLCE1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C, epsilon 1 (PLCE1) antibodyPLCE1 适用: 小鼠, 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C, epsilon 1 (PLCE1) (AA 4-735) antibodyPLCE1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300,IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- PLCE1 (Phospholipase C, epsilon 1 (PLCE1))
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别名
- PLCE1
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背景
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, Pancreas-enriched phospholipase C, Phosphoinositide phospholipase C-epsilon-1, Phospholipase C-epsilon-1, PLC-epsilon-1PLCE1 encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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分子量
- 253kD
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基因ID
- 51196
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UniProt
- Q9P212
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途径
- EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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