SYNE2 抗体 (AA 3765-5590)
Quick Overview for SYNE2 抗体 (AA 3765-5590) (ABIN7601532)
抗原
See all SYNE2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3765-5590
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原理
- Anti-Nesprin 2/SYNE2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Nesprin 2/SYNE2 Antibody Picoband® (ABIN7601532). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Nesprin 2/SYNE2 recombinant protein (Position: Q3765-Q5590).
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亚型
- IgG
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anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) (AA 6-296) antibody
SYNE2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) (AA 6702-6799) antibodySYNE2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 5E5 unconjugated
anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) (AA 1-176) antibodySYNE2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) (AA 1843-1877) antibodySYNE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB56750 unconjugated
anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) (AA 6702-6799) antibodySYNE2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) (AA 1-459) antibodySYNE2 适用: 人 WB, IP, IF, ICC, EM 宿主: 小鼠 Monoclonal K20-478-5 unconjugated
anti-Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) antibodySYNE2 适用: 小鼠 WB, IP, IF, ICC 宿主: 兔 Monoclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Monkey
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Apel, E. D., Lewis, R. M., Grady, R. M., Sanes, J. R. Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J. Biol. Chem. 275: 31986-31995, 2000. 2. Libotte, T., Zaim, H., Abraham, S., Padmakumar, V. C., Schneider, M., Lu, W., Munck, M., Hutchison, C., Wehnert, M., Fahrenkrog, B., Sauder, U., Aebi, U., Noegel, A. A., Karakesisoglou, I. Lamin A/C-dependent localization of nesprin-2, a giant scaffolder at the nuclear envelope. Molec. Biol. Cell 16: 3411-3424, 2005. 3. Maddox, D. M., Collin, G. B., Ikeda, A., Pratt, C. H., Ikeda, S., Johnson, B. A., Hurd, R. E., Shopland, L. S., Naggert, J. K., Chang, B., Krebs, M. P., Nishina, P. M. A mutation in Syne2 causes early retinal defects in photoreceptors, secondary neurons, and Mueller glia. Invest. Ophthal. Vis. Sci. 56: 3776-3787, 2015. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))
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别名
- SYNE2
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背景
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Synonyms: E3 SUMO-protein ligase PIAS3, Protein inhibitor of activated STAT protein 3, PIAS3
Tissue Specificity: Widely expressed.
Background: Nesprin-2 is a protein that in humans is encoded by the SYNE2 gene. The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.
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分子量
- 50-60 kDa
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基因ID
- 23224
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途径
- Maintenance of Protein Location
抗原
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