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MECP2 抗体 (AA 36-437)

Name: MECP2 抗体 (AA 36-437)
SKU: ABIN7601476
Availability: OutOfStock

This anti-MECP2 antibody is a 兔多克隆 antibody detecting MECP2 in WB, ELISA 和 IHC. Suitable for 人, 小鼠, 大鼠和猴.

产品编号 ABIN7601476

发货至: 中国

Quick Overview for MECP2 抗体 (AA 36-437) (ABIN7601476)

抗原

See all MECP2 抗体

MECP2 (Methyl CpG Binding Protein 2 (MECP2))

适用

人, 小鼠, 大鼠, 猴

宿主

兔

克隆类型

多克隆

标记

This MECP2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Discover our top product MECP2 Primary Antibody

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AA 36-437

原理

Anti-MECP2 Antibody Picoband®

产品特性

Anti-MECP2 Antibody Picoband® (ABIN7601476). Tested in WB, IHC, ELISA applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human MECP2 recombinant protein (Position: K36-Q437). Human MECP2 shares 95.8% and 96% amino acid (aa) sequence identity with mouse and rat MECP2, respectively.
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 7-148) antibody
MECP2 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8H4A5B9 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 81-170) antibody
MECP2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B11 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-486) antibody
MECP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-100) antibody
MECP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (pSer423) antibody
MECP2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB29261 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (C-Term) antibody
MECP2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 400-428) antibody
MECP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB25959 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 81-170) antibody
MECP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4B6 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (N-Term) antibody
MECP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-100) antibody
MECP2 适用: 人 IF 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.25-0.5 μg/mL, Human, Monkey, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY(October 1999). "Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2". Nat. Genet. 23 (2): 185-8. 2. Chahrour M, et al. (2008). "MECP2, a key contributor to neurological disease, activates and represses transcription". Science. 320 (5880): 1224-9.

限制

仅限研究用
状态

Lyophilized

溶解方式

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

储存条件

4 °C,-20 °C

储存方法

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
抗原

MECP2 (Methyl CpG Binding Protein 2 (MECP2))

别名

MECP2

背景

MECP2?(methyl CpG binding protein 2) is a?gene?that encodes the?protein?MECP2. It is mapped to Xq28. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

分子量

80 kDa

基因ID

4204

UniProt

P51608

途径

Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane