SYNGAP1 抗体 (AA 3-1175)
Quick Overview for SYNGAP1 抗体 (AA 3-1175) (ABIN7601169)
抗原
See all SYNGAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-1175
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原理
- Anti-SYNGAP1 Antibody Picoband®
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产品特性
- Anti-SYNGAP1 Antibody Picoband® (ABIN7601169). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SYNGAP1 recombinant protein (Position: R3-R1175). Human SYNGAP1 shares 99% and 99.1% amino acid (aa) sequence identity with mouse and rat SYNGAP1, respectively.
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anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (AA 1161-1343) antibody
SYNGAP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (C-Term) antibodySYNGAP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (AA 60-72) antibodyVerified SYNGAP1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (AA 1169-1183) antibodyVerified SYNGAP1 适用: 人, 小鼠 WB, ELISA, IF, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) antibodySYNGAP1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (AA 1185-1199) antibodySYNGAP1 适用: 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Berryer, M. H., Hamdan, F. F., Klitten, L. L., Moller, R. S., Carmant, L., Schwartzentruber, J., Patry, L., Dobrzeniecka, S., Rochefort, D., Neugnot-Cerioli, M., Lacaille, J.-C., Niu, Z., and 15 others. Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency. Hum. Mutat. 34: 385-394, 2013. 2. Carvill, G. L., Heavin, S. B., Yendle, S. C., McMahon, J. M., O'Roak, B. J., Cook, J., Khan, A., Dorschner, M. O., Weaver, M., Calvert, S., Malone, S., Wallace, G., and 22 others. Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1. Nature Genet. 45: 825-830, 2013. 3. Chen, H.-J., Rojas-Soto, M., Oguni, A., Kennedy, M. B. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20: 895-904, 1998. Note: Erratum: Neuron 33: 151 only, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))
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别名
- SYNGAP1
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背景
- Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants.
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分子量
- 148 kDa
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基因ID
- 8831
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途径
- Regulation of long-term Neuronal Synaptic Plasticity
抗原
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