NCOA2 抗体 (AA 297-1071)
Quick Overview for NCOA2 抗体 (AA 297-1071) (ABIN7601165)
抗原
See all NCOA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 297-1071
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原理
- Anti-NCOA2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-NCOA2 Antibody Picoband® (ABIN7601165). Tested in WB, IF, IHC, ICC, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human NCOA2 recombinant protein (Position: E297-E1071). Human NCOA2 shares 93.4% and 90.8% amino acid (aa) sequence identity with mouse and rat NCOA2, respectively.
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亚型
- IgG
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anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 550-820) antibody
NCOA2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (N-Term) antibodyNCOA2 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 706-739) antibodyNCOA2 适用: 人 WB 宿主: 兔 Polyclonal RB54073 unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 1169-1203), (C-Term) antibodyNCOA2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50717 unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 1431-1462) antibodyNCOA2 适用: 人 WB 宿主: 兔 Polyclonal RB53913 unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (C-Term) antibodyNCOA2 适用: 人, 小鼠 WB, IHC, IP, IHC (p), IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (N-Term) antibodyNCOA2 适用: 人, 小鼠, 大鼠, 犬, 兔, 马, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 702-751), (pSer736) antibodyNCOA2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, Human
1. Aikawa, Y., Katsumoto, T., Zhang, P., Shima, H., Shino, M., Terui, K., Ito, E., Ohno, H., Stanley, E. R., Singh, H., Tenen, D. G., Kitabayashi, I. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. (Letter) Nature Med. 16: 580-585, 2010. 2. Carapeti, M., Aguiar, R. C., Goldman, J. M., Cross, N. C. P. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. Blood 91: 3127-3133, 1998. 3. Chen, S. L., Dowhan, D. H., Hosking, B. M., Muscat, G. E. O. The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev. 14: 1209-1228, 2000. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))
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别名
- NCOA2
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背景
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Synonyms: NCOA2, BHLHE75, SRC2, TIF2, Nuclear receptor coactivator 2, NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
Background: The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.
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分子量
- 160-170 kDa
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基因ID
- 10499
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UniProt
- Q15596
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
抗原
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