OPA1 抗体 (AA 296-562)
Quick Overview for OPA1 抗体 (AA 296-562) (ABIN7601164)
抗原
See all OPA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 296-562
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原理
- Anti-OPA1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-OPA1 Antibody Picoband® (ABIN7601164). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human OPA1 recombinant protein (Position: D296-Q562).
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亚型
- IgG
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anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 661-960) antibody
OPA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 851-960) antibodyOPA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8A20 unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 919-955), (C-Term) antibodyOPA1 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF, IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 651-750) antibodyOPA1 适用: 人, 大鼠, 小鼠, 小鸡, 兔 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 183-418) antibodyOPA1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 1-960) antibodyOPA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 1-960) antibodyOPA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 183-351) antibodyOPA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 851-960) antibodyOPA1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C10 unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS (Nov 2014). "OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand". The EMBO Journal 33 (22): 2676-91. 2. Santarelli R, Rossi R, Scimemi P, Cama E, Valentino ML, La Morgia C, Caporali L, Liguori R, Magnavita V, Monteleone A, Biscaro A, Arslan E, Carelli V (Mar 2015). "OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation". Brain 138 (Pt 3): 563-76. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
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别名
- OPA1
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背景
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Synonyms: Hereditary hemochromatosis protein,HLA-H,HFE,HLAH,
Tissue Specificity: Expressed in all tissues tested except brain.
Background: Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
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分子量
- 80-100 kDa
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基因ID
- 4976
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UniProt
- O60313
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途径
- Tube Formation
抗原
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