AKR7A2 抗体 (AA 294-359)
Quick Overview for AKR7A2 抗体 (AA 294-359) (ABIN7601157)
抗原
See all AKR7A2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 294-359
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原理
- Anti-AKR7A2 Picoband® Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-AKR7A2 Picoband® Antibody (ABIN7601157). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human AKR7A2 recombinant protein (Position: A294-R359).
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亚型
- IgG
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anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) (AA 1-330) antibody
AKR7A2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) (AA 1-330) antibodyAKR7A2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A6 unconjugated
anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) antibodyAKR7A2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) (AA 100-359) antibodyAKR7A2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) (AA 1-330) antibodyAKR7A2 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2H3 unconjugated
anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) (AA 1-330) antibodyAKR7A2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) (Internal Region) antibodyAKR7A2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aflatoxin Beta1 Aldehyde Reductase (AKR7A2) antibodyAKR7A2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ireland, L. S., Harrison, D. J., Neal, G. E., Hayes, J. D. Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B(1)-aldehyde reductase. Biochem. J. 332: 21-34, 1998. 2. Kelly, V. P., Sherratt, P. J., Crouch, D. H., Hayes, J. D. Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of reductase 7 family proteins. Biochem. J. 366: 847-861, 2002. 3. Praml, C., Savelyeva, L., Schwab, M. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. Oncogene 22: 4765-4773, 2003. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- AKR7A2 (Aflatoxin Beta1 Aldehyde Reductase (AKR7A2))
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别名
- AKR7A2
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背景
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Synonyms: Aflatoxin B1 aldehyde reductase member 2, AFB1 aldehyde reductase 1, AFB1-AR 1, Aldoketoreductase 7, Succinic semialdehyde reductase, SSA reductase, AKR7A2, AFAR, AFAR1, AKR7
Tissue Specificity: Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues.
Background: Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene. It is mapped to 1p36.13. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.
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分子量
- 36 kDa
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基因ID
- 8574
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UniProt
- O43488
抗原
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