FDPS 抗体 (AA 29-397)
Quick Overview for FDPS 抗体 (AA 29-397) (ABIN7601131)
抗原
See all FDPS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 29-397
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原理
- Anti-FDPS/FPS Picoband® Antibody
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-FDPS/FPS Picoband® Antibody (ABIN7601131). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human FDPS/FPS recombinant protein (Position: S29-Q397).
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亚型
- IgG
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Heinzmann, C., Clarke, C. F., Klisak, I., Mohandas, T., Sparkes, R. S., Edwards, P. A., Lusis, A. J. Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. Genomics 5: 493-500, 1989. 2. Krisans, S. K., Ericsson, J., Edwards, P. A., Keller, G. A. Farnesyl-diphosphate synthase is localized in peroxisomes. J. Biol. Chem. 269: 14165-14169, 1994. 3. Scott, A. F. Personal Communication. Baltimore, Md. 11/9/2006. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FDPS (Farnesyl Diphosphate Synthase (FDPS))
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别名
- FDPS
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背景
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Synonyms: Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Tissue Specificity: Expressed ubiquitously.
Background: Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene. It is mapped to 1q22. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
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分子量
- 40 kDa
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基因ID
- 2224
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UniProt
- P14324
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途径
- Regulation of Muscle Cell Differentiation
抗原
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