PTPN12 抗体 (AA 276-311)
Quick Overview for PTPN12 抗体 (AA 276-311) (ABIN7601051)
抗原
See all PTPN12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 276-311
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原理
- Anti-PTPN12 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PTPN12 Antibody Picoband® (ABIN7601051). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PTPN12 recombinant protein (Position: A276-D311).
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亚型
- IgG
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anti-Protein Tyrosine Phosphatase G1 (PTPN12) antibody
PTPN12 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) (N-Term) antibodyPTPN12 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) antibodyPTPN12 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) (AA 682-779) antibodyPTPN12 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G6 unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) (AA 539-714) antibodyPTPN12 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) antibodyPTPN12 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4G6 unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) (AA 681-714) antibodyPTPN12 适用: 人 WB 宿主: 兔 Polyclonal RB54521 unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) (AA 724-756) antibodyPTPN12 适用: 人 WB 宿主: 兔 Polyclonal RB54520 unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) (AA 1-780) antibodyPTPN12 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Tyrosine Phosphatase G1 (PTPN12) (AA 591-640) antibodyPTPN12 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Charest, A., Wagner, J., Muise, E. S., Heng, H. H. Q., Tremblay, M. L. Structure of the murine MPTP-PEST gene: genomic organization and chromosomal mapping. Genomics 28: 501-507, 1995. 2. Cong, F., Spencer, S., Cote, J.-F., Wu, Y., Tremblay, M. L., Lasky, L. A., Goff, S. P. Cytoskeletal protein PSTPIP1 s the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation. Molec. Cell 6: 1413-1423, 2000. 3. Spencer, S., Dowbenko, D., Cheng, J., Li, W., Brush, J., Utzig, S., Simanis, V., Lasky, L. A. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for PEST tyrosine phosphatase. J. Cell Biol. 138: 845-860, 1997. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
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别名
- PTPN12
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背景
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Synonyms: Platelet basic protein, PBP, C-X-C motif chemokine 7, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF, Small-inducible cytokine B7, PPBP, CTAP3, CXCL7, SCYB7, TGB1, THBGB1, NAP-2
Background: Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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分子量
- 110 kDa
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基因ID
- 5782
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UniProt
- Q05209
抗原
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