TLR4 抗体 (AA 26-827)
Quick Overview for TLR4 抗体 (AA 26-827) (ABIN7600972)
抗原
See all TLR4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 26-827
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原理
- Anti-Tlr4 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Tlr4 Antibody Picoband® (ABIN7600972). Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse Tlr4 recombinant protein (Position: N26-E827).
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亚型
- IgG
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anti-Toll-Like Receptor 4 (TLR4) (AA 751-835) antibody
TLR4 适用: 人, 小鼠, 大鼠, Cow WB, FACS, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibodyTLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 4 (TLR4) (AA 49-247) antibodyTLR4 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (HRP)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal HRP
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (FITC)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal FITC
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (Biotin)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal Biotin
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (PE)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal PE
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (APC)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal APC
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (PerCP)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal PerCP
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (Atto 488)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488
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应用备注
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Western blot, 0.5-1 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Aderem, A., Ulevitch, R. J. Toll-like receptors in the induction of the innate immune response. Nature 406: 782-787, 2000. 2. Andonegui, G., Bonder, C. S., Green, F., Mullaly, S. C., Zbytnuik, L., Raharjo, E., Kubes, P. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J. Clin. Invest. 111: 1011-1020, 2003. Note: Erratum: J. Clin. Invest. 112: 1264 only, 2003. 3. Andonegui, G., Zhou, H., Bullard, D., Kelly, M. M., Mullaly, S. C., McDonald, B., Long, E. M., Robbins, S. M., Kubes, P. Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic gram-negative bacterial infection. J. Clin. Invest. 119: 1921-1930, 2009. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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别名
- Tlr4
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背景
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Synonyms: Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1
Tissue Specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
Background: Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls.
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分子量
- 96 kDa
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基因ID
- 21898
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
抗原
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