RNASEL 抗体 (AA 24-735)
Quick Overview for RNASEL 抗体 (AA 24-735) (ABIN7600857)
抗原
See all RNASEL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 24-735
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原理
- Anti-RNase L/Rnasel Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-RNase L/Rnasel Antibody Picoband® (ABIN7600857). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse RNase L/Rnasel recombinant protein (Position: E24-S735).
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亚型
- IgG
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anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) (AA 472-741) antibody
RNASEL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) antibodyRNASEL 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) (AA 358-583) antibodyRNASEL 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) (AA 330-741) antibodyRNASEL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) (AA 619-728) antibodyRNASEL 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) (AA 619-728) antibodyRNASEL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) (AA 140-167), (N-Term) antibodyRNASEL 适用: 小鼠 WB 宿主: 兔 Polyclonal RB37131 unconjugated
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) antibodyRNASEL 适用: 人, 猴 WB, ELISA 宿主: 小鼠 Monoclonal (2E9) unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. RNase L inhibitor: a new component of the interferon-regulated 2-5A pathway. J. Biol. Chem. 270: 13308-13317, 1995. 2. Carpten, J., Nupponen, N., Isaacs, S., Sood, R., Robbins, C., Xu, J., Faruque, M., Moses, T., Ewing, C., Gillanders, E., Hu, P., Bujnovszky, P., and 29 others. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nature Genet. 30: 181-184, 2002. 3. Casey, G., Neville, P. J., Plummer, S. J., Xiang, Y., Krumroy, L. M., Klein, E. A., Catalona, W. J., Nupponen, N., Carpten, J. D., Trent, J. M., Silverman, R. H., Witte, J. S. RNASEL arg462gln variant is implicated in up to 13 % of prostate cancer cases. Nature Genet. 32: 581-583, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))
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别名
- Rnasel
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背景
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Synonyms: Endothelin-converting enzyme 1,ECE-1,3.4.24.71,ECE1,
Tissue Specificity: All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma, isoforms A and C in liver, testis and small intestine, isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells, isoforms C and D in saphenous vein cells, and isoform C in kidney. .
Background: RNase L is an enzyme that in humans is encoded by the RNASEL gene. This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.
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分子量
- 83 kDa
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基因ID
- 24014
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UniProt
- Q05921
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途径
- Hepatitis C
抗原
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