TEK 抗体 (AA 23-616)
Quick Overview for TEK 抗体 (AA 23-616) (ABIN7600762)
抗原
See all TEK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-616
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原理
- Anti-TIE2/TEK Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-TIE2/TEK Antibody Picoband® (ABIN7600762). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human TIE2/TEK recombinant protein (Position: A23-R616).
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亚型
- IgG
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anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 66-185) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A5 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 571-748) antibodyTEK 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F5B9 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789) antibodyTEK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibodyTEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 401-550) antibodyTEK 适用: 人, 小鼠, 大鼠, Cow ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 286-465) antibodyTEK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibodyTEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (C-Term) antibodyTEK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 500-750) antibodyTEK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789), (C-Term) antibodyTEK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01525-01526 unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., Suda, T. Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-161, 2004. 2. Ramsden, J. D., Cocks, H. C., Shams, M., Nijjar, S., Watkinson, J. C., Sheppard, M. C., Ahmed, A., Eggo, M. C. Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3-prime,5-prime-monophosphate. J. Clin. Endocr. Metab. 86: 2709-2716, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
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别名
- TEK
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背景
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Synonyms: Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p140 TEK, CD202b, TEK, TIE2, VMCM, VMCM1
Tissue Specificity: Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma. Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been ly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
Background: TIE2, also known as TEK tyrosine kinase, is mapped to 9p21.2. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
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分子量
- 160 kDa
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基因ID
- 7010
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UniProt
- Q02763
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途径
- RTK signaling, Growth Factor Binding
抗原
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