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CD3D 抗体 (AA 22-171)

This anti-CD3D antibody is a 兔 多克隆 antibody detecting CD3D in WB, ELISA 和 FACS. Suitable for 人.
产品编号 ABIN7600678
发货至: 中国

Quick Overview for CD3D 抗体 (AA 22-171) (ABIN7600678)

抗原

See all CD3D 抗体
CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

适用

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宿主

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克隆类型

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多克隆

标记

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This CD3D antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • 抗原表位

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    AA 22-171

    原理

    Anti-CD3D Antibody Picoband®

    产品特性

    Anti-CD3D Antibody Picoband® (ABIN7600678). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human CD3D recombinant protein (Position: F22-K171). Human CD3D shares 66% and 70.7% amino acid (aa) sequence identity with mouse and rat CD3D, respectively.
  • 应用备注

    Western blot, 0.2-0.5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Dadi, H. K., Simon, A. J., Roifman, C. M. Effect of CD3-delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. New Eng. J. Med. 349: 1821-1828, 2003. Note: Erratum: New Eng. J. Med. 350: 1803 only, 2004. 2. de Saint Basile, G., Geissmann, F., Flori, E., Uring-Lambert, B., Soudais, C., Cavazzana-Calvo, M., Durandy, A., Jabado, N., Fischer, A., Le Diest, F. Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3. J. Clin. Invest. 114: 1512-1517, 2004. 3. Delgado, P., Fernandez, E., Dave, V., Kappes, D., Alarcon, B. CD3-delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature 406: 426-430, 2000.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    储存条件

    4 °C,-20 °C

    储存方法

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原

    CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

    别名

    CD3D

    背景

    T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene. The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.

    分子量

    19 kDa

    基因ID

    915

    UniProt

    P04234

    途径

    TCR Signaling, CXCR4-mediated Signaling Events
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