ZBP1 抗体 (AA 2-421)
Quick Overview for ZBP1 抗体 (AA 2-421) (ABIN7600499)
抗原
See all ZBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-421
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原理
- Anti-DAI/ZBP1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-DAI/ZBP1 Antibody Picoband® (ABIN7600499). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human DAI/ZBP1 recombinant protein (Position: A2-E421).
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亚型
- IgG
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anti-Z-DNA Binding Protein 1 (ZBP1) (AA 10-167) antibody
ZBP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (AA 2-100) antibodyZBP1 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 2C10 unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (AA 1-411) antibodyZBP1 适用: 人, 小鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal Zippy-1 unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (AA 144-193) antibodyZBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (AA 1-200) antibodyZBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (C-Term) antibodyZBP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Fu, Y., Comella, N., Tognazzi, K., Brown, L. F., Dvorak, H. F., Kocher, O. Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display. Gene 240: 157-163, 1999. 2. Jiao, H., Wachsmuth, L., Kumari, S., Schwarzer, R., Lin, J., Eren, R. O., Fisher, A., Lane, R., Young, G. R., Kassiotis, G., Kaiser, W. J., Pasparakis, M. Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature 580: 391-395, 2020. Note: Erratum: Nature 580: E10, 2020. Electronic Article. 3. Rothenburg, S., Schwartz, T., Koch-Nolte, F., Haag, F. Complex regulation of the human gene for the Z-DNA binding protein DLM-1. Nucleic Acids Res. 30: 993-1000, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- ZBP1 (Z-DNA Binding Protein 1 (ZBP1))
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别名
- ZBP1
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背景
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Synonyms: C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2
Tissue Specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
Background: Z-DNA-binding protein 1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, is a protein that in humans is encoded by the ZBP1 gene. This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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分子量
- 63 kDa
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基因ID
- 81030
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UniProt
- Q9H171
抗原
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