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SBDS 抗体 (AA 19-241)

This anti-SBDS antibody is a 兔 多克隆 antibody detecting SBDS in WB, ELISA, IF, ICC 和 FACS. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7600404
发货至: 中国

Quick Overview for SBDS 抗体 (AA 19-241) (ABIN7600404)

抗原

See all SBDS 抗体
SBDS (Shwachman-Bodian-Diamond Syndrome (SBDS))

适用

  • 35
  • 15
  • 15
  • 7
  • 4
  • 4
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  • 3
  • 3
  • 2
  • 2
人, 小鼠, 大鼠

宿主

  • 33
  • 2

克隆类型

  • 30
  • 5
多克隆

标记

  • 18
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
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  • 1
This SBDS antibody is un-conjugated

应用范围

  • 17
  • 10
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  • 5
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  • 2
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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)
  • 抗原表位

    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    AA 19-241

    原理

    Anti-SBDS Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-SBDS Antibody Picoband® (ABIN7600404). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human SBDS recombinant protein (Position: R19-D241).

    亚型

    IgG
  • 应用备注

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Austin, K. M., Gupta, M. L., Jr., Coats, S. A., Tulpule, A., Mostoslavsky, G., Balazs, A. B., Mulligan, R. C., Daley, G., Pellman, D., Shimamura, A. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J. Clin. Invest. 118: 1511-1518, 2008. 2. Austin, K. M., Leary, R. J., Shimamura, A. The Shwachman-Diamond SBDS protein localizes to the nucleolus. Blood 106: 1253-1258, 2005. 3. Ball, H. L., Zhang, B., Riches, J. J., Gandhi, R., Li, J., Rommens, J. M., Myers, J. S. Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses. Hum. Molec. Genet. 18: 3684-3695, 2009.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    储存条件

    4 °C,-20 °C

    储存方法

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原

    SBDS (Shwachman-Bodian-Diamond Syndrome (SBDS))

    别名

    SBDS

    背景

    Synonyms: Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12, CASP2, ICH1, NEDD2

    Tissue Specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

    Background: Ribosome maturation protein SBDS is a protein that in humans is encoded by the SBDS gene. This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located.

    分子量

    32 kDa

    基因ID

    51119

    UniProt

    Q9Y3A5

    途径

    Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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