AGRN 抗体 (AA 1864-2068)
Quick Overview for AGRN 抗体 (AA 1864-2068) (ABIN7600387)
抗原
See all AGRN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1864-2068
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原理
- Anti-Agrin/AGRN Picoband® Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Agrin/AGRN Picoband® Antibody (ABIN7600387). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Agrin/AGRN recombinant protein (Position: S1864-P2068).
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亚型
- IgG
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anti-Agrin (AGRN) (AA 1206-1475) antibody
AGRN 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1329-1548) antibodyAGRN 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 968-1130) antibodyAGRN 适用: 人 IHC, WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 30-350) antibodyAGRN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1856-2045) antibodyAGRN 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1130-1401) antibodyAGRN 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (N-Term) antibodyAGRN 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (C-Term) antibodyAGRN 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bassat, E., Mutlak, Y. E., Genzelinakh, A., Shadrin, I. Y., Umansky, K. B., Yifa, O., Kain, D., Rajchman, D., Leach, J., Bassat, D. R., Udi, Y., Sarig, R., Sagi, I., Martin, J. F., Bursac, N., Cohen, S., Tzahor, E. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature 547: 179-184, 2017. 2. Burgess, R. W., Nguyen, Q.T., Son, Y. J., Lichtman, J. W., Sanes, J. R. Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction. Neuron 23: 33-44, 1999. 3. Campanelli, J. T., Hoch, W., Rupp, F., Kreiner, T., Scheller, R. H. Agrin mediates cell contact-induced acetylcholine receptor clustering. Cell 67: 909-916, 1991. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- AGRN (Agrin (AGRN))
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别名
- AGRN
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背景
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Synonyms: Agrin, Agrin N-terminal 110 kDa subunit, Agrin C-terminal 110 kDa subunit, Agrin C-terminal 90 kDa fragment, C90, Agrin C-terminal 22 kDa fragment, C22, AGRN, AGRIN
Tissue Specificity: Brain specific. Detected in neuronal cells.
Background: Agrin is a protein that in humans is encoded by the AGRN gene. It is mapped to 1p36.33. This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms.
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分子量
- 205-217 kDa
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基因ID
- 375790
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UniProt
- O00468
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途径
- Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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