AGRN 抗体 (AA 968-1130)
-
- 抗原 See all AGRN 抗体
- AGRN (Agrin (AGRN))
-
抗原表位
- AA 968-1130
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This AGRN antibody is un-conjugated
-
应用范围
- Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Agrin protein (968-1130AA)
- 亚型
- IgG
- Top Product
- Discover our top product AGRN Primary Antibody
-
anti-Agrin (AGRN) (AA 1206-1475) antibody
AGRN 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1329-1548) antibodyAGRN 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 30-350) antibodyAGRN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1856-2045) antibodyAGRN 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1130-1401) antibodyAGRN 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (C-Term) antibodyAGRN 适用: 大鼠, 小鼠 IHC, WB, ICC 宿主: 小鼠 Monoclonal Agr-33 unconjugated
anti-Agrin (AGRN) (N-Term) antibodyAGRN 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (C-Term) antibodyAGRN 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500, IF:1:50-1:200,
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- AGRN (Agrin (AGRN))
- 别名
- AGRN (AGRN 产品)
- 别名
- AGRIN antibody, agrn antibody, wu:fb57e07 antibody, Agrin antibody, nmf380 antibody, AGR antibody, HSPG antibody, agrin antibody, LOC465392 antibody, agrn antibody, AGRN antibody, Agrn antibody
- 背景
-
Background: Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.
Aliases: AGRIN antibody, Agrin C-terminal 22 kDa fragment antibody, Agrin proteoglycan antibody, AGRIN_HUMAN antibody, Agrn antibody, C22 antibody, C90 antibody, FLJ45064 antibody, OTTHUMP00000044043 antibody
- UniProt
- O00468
- 途径
- Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
-
