GAB2 抗体 (AA 162-504)
Quick Overview for GAB2 抗体 (AA 162-504) (ABIN7600208)
抗原
See all GAB2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 162-504
-
原理
- Anti-GAB2 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-GAB2 Antibody Picoband® (ABIN7600208). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human GAB2 recombinant protein (Position: S162-R504).
-
亚型
- IgG
-
-
anti-GRB2-Associated Binding Protein 2 (GAB2) (pTyr452) antibody
GAB2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (pSer159) antibodyGAB2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (AA 273-484) antibodyGAB2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (Ser159) antibodyGAB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (AA 3-30), (N-Term) antibodyGAB2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB21209 unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (AA 601-676) antibodyGAB2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (AA 357-607) antibodyGAB2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (pTyr643) antibodyGAB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (pSer623) antibodyGAB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 2 (GAB2) (C-Term) antibodyGAB2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.1-0.25 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bentires-Alj, M., Gil, S. G., Chan, R., Wang, Z. C., Wang, Y., Imanaka, N., Harris, L. N., Richardson, A., Neel, B. G., Gu, H. A role for the scaffolding adapter GAB2 in breast cancer. Nature Med. 12: 114-121, 2006. 2. Chapuis, J., Hannequin, D., Pasquier, F., Bentham, P., Brice, A., Leber, I., Frebourg, T., Deleuze, J.-F., Cousin, E., Thaker, U., Amouyel, P., Mann, D., Lendon, C., Campion, D., Lambert, J.-C. Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiol. Dis. 30: 103-106, 2008. 3. Gu, H., Saito, K., Klaman, L. D., Shen, J., Fleming, T., Wang, Y.-P., Pratt, J. C., Lin, G., Lim, B., Kinet, J.-P., Neel, B. G. Essential role for Gab2 in the allergic response. Nature 412: 186-190, 2001. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- GAB2 (GRB2-Associated Binding Protein 2 (GAB2))
-
别名
- GAB2
-
背景
-
Synonyms: Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12, CASP2, ICH1, NEDD2
Tissue Specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Background: GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene
-
分子量
- 90 kDa
-
基因ID
- 9846
-
途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, Warburg Effect
抗原
-
