Neurofibromin 1 抗体 (AA 160-270)
Quick Overview for Neurofibromin 1 抗体 (AA 160-270) (ABIN7600197)
抗原
See all Neurofibromin 1 (NF1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 160-270
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原理
- Anti-Neurofibromin/NF1 Antibody Picoband® (monoclonal, 4F8B7)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Neurofibromin/NF1 Antibody Picoband® (monoclonal, 4F8B7) (ABIN7600197). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Neurofibromin/NF1 recombinant protein (Position: R160-Q270).
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亚型
- IgG2a
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anti-Neurofibromin 1 (NF1) (Internal Region) antibody
NF1 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 1 (NF1) (AA 655-892) antibodyNF1 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 1 (NF1) (AA 1551-1600) antibodyNF1 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 1 (NF1) (AA 2719-2818) antibodyNF1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Neurofibromin 1 (NF1) antibodyNF1 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 1 (NF1) (Center) antibodyNF1 适用: 人, 小鼠, 大鼠, 小鸡, 猴, Pig WB, IF, IHC, IC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 1 (NF1) (Internal Region) antibodyNF1 适用: 人, 小鼠, 大鼠 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 1 (NF1) (AA 1551-1600) antibodyNF1 适用: 人, 小鼠, 大鼠 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 1 (NF1) (N-Term) antibodyNF1 适用: 人, 小鼠, 大鼠, 豚鼠 ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal McNFn27 unconjugated
anti-Neurofibromin 1 (NF1) (N-Term) antibodyNF1 适用: 人, 小鼠, 大鼠, 豚鼠 ELISA, WB, IP 宿主: 小鼠 Monoclonal McNFn27a unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Scheffzek K, Welti S (2012). "Neurofibromin: Protein Domains and Functional Characteristics". In Upadhyaya M, Cooper D (eds.). Neurofibromatosis Type 1. Berlin, Heidelberg: Springer. pp. 305-326. 2. Trovó-Marqui AB, Tajara EH (July 2006). "Neurofibromin: a general outlook". Clinical Genetics. 70 (1): 1-13. 3. Peltonen S, Pöyhönen M (2012). "Clinical Diagnosis and Atypical Forms of NF1". In Upadhyaya M, Cooper D (eds.). Neurofibromatosis Type 1. Berlin, Heidelberg: Springer. pp. 17-30. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Neurofibromin 1 (NF1)
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别名
- NF1
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背景
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Synonyms: Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84, STAT1
Tissue Specificity: Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level).
Background: Neurofibromin 1 (NF1) is a gene in humans that is located on chromosome 17. This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
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分子量
- 319 kDa
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基因ID
- 4763
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UniProt
- P21359
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途径
- cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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