TCF4 抗体 (AA 147-176)
Quick Overview for TCF4 抗体 (AA 147-176) (ABIN7600080)
抗原
See all TCF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 147-176
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原理
- Anti-TCF4 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-TCF4 Antibody Picoband® (ABIN7600080). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human TCF4 recombinant protein (Position: Q147-V176).
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亚型
- IgG
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anti-Transcription Factor 4 (TCF4) (AA 1-365) antibody
TCF4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G4 unconjugated
anti-Transcription Factor 4 (TCF4) (AA 400-500) antibodyTCF4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 4 (TCF4) (AA 518-667) antibodyTCF4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 7B1B3 unconjugated
anti-Transcription Factor 4 (TCF4) (AA 518-667) antibodyTCF4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4D4C4 unconjugated
anti-Transcription Factor 4 (TCF4) (AA 419-525) antibodyTCF4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 4 (TCF4) (N-Term) antibodyTCF4 适用: 人, 小鼠, 马, 豚鼠, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 4 (TCF4) (AA 365-671) antibodyTCF4 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal TCF4-1705 unconjugated
anti-Transcription Factor 4 (TCF4) (AA 73-122) antibodyTCF4 适用: 人, 小鼠, 大鼠, 马, Pig, 犬, 猴, Cow, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 4 (TCF4) antibodyTCF4 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 4 (TCF4) (N-Term) antibodyTCF4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Amiel, J., Rio, M., de Pontual, L., Redon, R., Malan, V., Boddaert, N., Plouin, P., Carter, N. P., Lyonnet, S., Munnich, A., Colleaux, L. Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. Am. J. Hum. Genet. 80: 988-993, 2007. 2. Breschel, T. S., McInnis, M. G., Margolis, R. L., Sirugo, G., Corneliussen, B., Simpson, S. G., McMahon, F. J., MacKinnon, D. F., Xu, J. F., Pleasant, N., Huo, Y., Ashworth, R. G., Grundstrom, C., Grundstrom, T., Kidd, K. K., DePaulo, J. R., Ross, C. A. A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1. Hum. Molec. Genet. 6: 1855-1863, 1997. 3. Brockschmidt, A., Todt, U., Ryu, S., Hoischen, A., Landwehr, C., Birnbaum, S., Frenck, W., Radlwimmer, B., Lichter, P., Engels, H., Driever, W., Kubisch, C., Weber, R. G. Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4. Hum. Molec. Genet. 16: 1488-1494, 2007. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- TCF4 (Transcription Factor 4 (TCF4))
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别名
- TCF4
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背景
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Synonyms: Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regulated kinase 1, SGK1, SGK
Tissue Specificity: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.
Background: Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located on chromosome 18q21.2. This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.
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分子量
- 71 kDa
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基因ID
- 6925
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UniProt
- P15884
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途径
- WNT signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus
抗原
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