CTNNA1 抗体 (AA 143-292)
Quick Overview for CTNNA1 抗体 (AA 143-292) (ABIN7600057)
抗原
See all CTNNA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 143-292
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原理
- Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband® (monoclonal, 10I2)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband® (monoclonal, 10I2) (ABIN7600057). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.
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亚型
- IgG1
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anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (C-Term) antibody
CTNNA1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 637-906) antibodyCTNNA1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) antibodyCTNNA1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 143-292) antibodyCTNNA1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibodyVerified CTNNA1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 371-574) antibodyCTNNA1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 8B6C1 unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 2-228) antibodyCTNNA1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 1-288) antibodyCTNNA1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 152-250) antibodyCTNNA1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4G6 unconjugated
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) antibodyCTNNA1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Vasioukhin, V., Bauer, C., Degenstein, L., Wise, B., Fuchs, E. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104: 605-617, 2001. 2. Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (November 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proc Natl Acad Sci U S A 88 (20): 9156-60. 3. "Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102 kDa" -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
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别名
- CTNNA1
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背景
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Synonyms: alpha catenin antibody, alpha E catenin antibody, Alpha E-catenin antibody, alphaE catenin antibody, Cadherin associated protein 102 kDa antibody, Cadherin associated protein antibody, Cadherin-associated protein antibody, CAP 102 antibody, CAP102 antibody, Catenin (cadherin associated protein) alpha 1 102 kDa antibody, Catenin (cadherin associated protein), alpha 1, 102 kDa antibody, Catenin alpha 1 antibody, Catenin alpha-1 antibody, CTNA1_HUMAN antibody, CTNNA 1 antibody, CTNNA1 antibody, FLJ36832 antibody, FLJ52416 antibody, NY REN 13 antigen antibody, OTTHUMP00000224141 antibody, OTTHUMP00000224147 antibody, Renal carcinoma antigen NY REN 13 antibody, Renal carcinoma antigen NY-REN-13 antibody
Tissue Specificity: Expressed ubiquitously in normal tissues.
Background: CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.
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分子量
- 100 kDa
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基因ID
- 1495
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UniProt
- P35221
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途径
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location
抗原
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