PAWR 抗体 (AA 13-333)
Quick Overview for PAWR 抗体 (AA 13-333) (ABIN7599938)
抗原
See all PAWR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 13-333
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原理
- Anti-PAR4/Pawr Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PAR4/Pawr Antibody Picoband® (ABIN7599938). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse PAR4/Pawr recombinant protein (Position: T13-R333).
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亚型
- IgG
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anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody
PAWR 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (C-Term) antibodyPAWR 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (AA 212-261) antibodyPAWR 适用: 人, 犬, 马, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibodyPAWR 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (AA 166-215) antibodyPAWR 适用: 人, 小鼠, 大鼠, 犬, 兔, 豚鼠, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (Middle Region) antibodyPAWR 适用: 人, 小鼠, 大鼠, 犬, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (Middle Region) antibodyPAWR 适用: 人, 小鼠, 大鼠, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (C-Term) antibodyPAWR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibodyPAWR 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (AA 291-340) antibodyPAWR 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Donninger, H., Hesson, L., Vos, M., Beebe, K., Gordon, L., Sidransky, D., Liu, J. W., Schlegel, T., Payne, S., Hartmann, A., Latif, F., Clark, G. J. The Ras effector RASSF2 controls the PAR-4 tumor suppressor. Molec. Cell. Biol. 30: 2608-2620, 2010. 2. Duan, W., Zhang, Z., Gash, D. M., Mattson, M. P. Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Ann. Neurol. 46: 587-597, 1999. 3. Johnstone, R. W., See, R. H., Sells, S. F., Wang, J., Muthukkumar, S., Englert, C., Haber, D. A., Licht, J. D., Sugrue, S. P., Roberts, T., Rangnekar, V. M., Shi, Y. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Molec. Cell. Biol. 16: 6945-6956, 1996. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))
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别名
- Pawr
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背景
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Synonyms: Protein ERGIC-53, ER-Golgi intermediate compartment 53 kDa protein, Gp58, Intracellular mannose-specific lectin MR60, Lectin mannose-binding 1, LMAN1, ERGIC53, F5F8D
Tissue Specificity: Ubiquitous.
Background: PRKC, apoptosis, WT1, regulator, also known as PAWR or Prostate apoptosis response-4 (Par-4), is a human gene. This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
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分子量
- 45 kDa
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基因ID
- 114774
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UniProt
- Q925B0
抗原
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