MECOM 抗体 (AA 125-743)
Quick Overview for MECOM 抗体 (AA 125-743) (ABIN7599882)
抗原
See all MECOM 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 125-743
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原理
- Anti-EVI1/MECOM Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-EVI1/MECOM Antibody Picoband® (ABIN7599882). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human EVI1/MECOM recombinant protein (Position: E125-D743).
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亚型
- IgG
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anti-MDS1 and EVI1 Complex Locus (MECOM) antibody
MECOM 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (C-Term) antibodyMECOM 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (AA 952-1050) antibodyMECOM 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6A9 unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (AA 80-169) antibodyMECOM 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E7 unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (C-Term) antibodyMECOM 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (N-Term) antibodyMECOM 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (AA 534-632) antibodyMECOM 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) antibodyMECOM 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (AA 1-50) antibodyMECOM 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-MDS1 and EVI1 Complex Locus (MECOM) (Internal Region) antibodyVerified MECOM 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Buonamici, S., Li, D., Chi, Y., Zhao, R., Wang, X., Brace, L., Ni, H., Saunthararajah, Y., Nucifora, G. EVI1 induces myelodysplastic syndrome in mice. J. Clin. Invest. 114: 713-719, 2004. Note: Erratum: J. Clin. Invest. 115: 2296 only, 2005. 2. Gross, M. B. Personal Communication. Baltimore, Md. 3/16/2018. 3. Morishita, K., Parganas, E., Bartholomew, C., Sacchi, N., Valentine, M. B., Raimondi, S. C., Le Beau, M. M., Ihle, J. N. The human Evi-1 gene is located on chromosome 3q24-q28 but is not rearranged in three cases of acute nonlymphocytic leukemias containing t(3,5)(q25,q34) translocations. Oncogene Res. 5: 221-231, 1990. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- MECOM (MDS1 and EVI1 Complex Locus (MECOM))
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别名
- MECOM
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背景
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Synonyms: Thioredoxin, mitochondrial, MTRX, Mt-Trx, Thioredoxin-2, TXN2, TRX2
Tissue Specificity: Widely expressed in adult (at protein level) and fetal tissues.
Background: MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
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分子量
- 138 kDa
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基因ID
- 2122
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UniProt
- Q03112
抗原
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