RNF20 抗体 (AA 123-389)
Quick Overview for RNF20 抗体 (AA 123-389) (ABIN7599859)
抗原
See all RNF20 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 123-389
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原理
- Anti-RNF20 Antibody Picoband® (monoclonal, 3C6E2)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-RNF20 Antibody Picoband® (monoclonal, 3C6E2) (ABIN7599859). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human RNF20 recombinant protein (Position: E123-S389).
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亚型
- IgG2b
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anti-Ring Finger Protein 20 (RNF20) (AA 1-975) antibody
RNF20 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (Internal Region) antibodyRNF20 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) antibodyRNF20 适用: 人 WB 宿主: 小鼠 Monoclonal 4C6 unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 177-276) antibodyRNF20 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 1-975) antibodyRNF20 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 177-276) antibodyRNF20 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 576-625) antibodyRNF20 适用: 人, 小鼠, 犬, Cow, 豚鼠, Pig, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 108-157) antibodyRNF20 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 1-260) antibodyRNF20 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (N-Term) antibodyRNF20 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
1. Blank, M., Tang, Y., Yamashita, M., Burkett, S. S., Cheng, S. Y., Zhang, Y. E. A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nature Med. 18: 227-234, 2012. 2. Cortez, J. T., Montauti, E., Shifrut, E., Gatchalian, J., Zhang, Y., Shaked, O., Xu, Y., Roth, T. L., Simeonov, D. R., Zhang, Y., Chen, S., Li, Z., and 13 others. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature 582: 416-420, 2020. 3. Dickinson, M. E., Flenniken, A. M., Ji, X., Teboul, L., Wong, M. D., White, J. K., Meehan, T. F., Weninger, W. J., Westerberg, H., Adissu, H., Baker, C. N., Bower, L., and 73 others. High-throughput discovery of novel developmental phenotypes. Nature 537: 508-514, 2016. Note: Erratum: Nature 551: 398 only, 2017. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- RNF20 (Ring Finger Protein 20 (RNF20))
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别名
- RNF20
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背景
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Synonyms: Survival motor neuron protein, Component of gems 1, Gemin-1, SMN1, SMN, SMNT, SMN2, SMNC
Tissue Specificity: Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).
Background: E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
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分子量
- 114 kDa
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基因ID
- 56254
抗原
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