CDSE1 抗体 (AA 1-775)
Quick Overview for CDSE1 抗体 (AA 1-775) (ABIN7599545)
抗原
See all CDSE1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-775
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原理
- Anti-CSDE1/NRU Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CSDE1/NRU Antibody Picoband® (ABIN7599545). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CSDE1/NRU recombinant protein (Position: M1-Q775).
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亚型
- IgG
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anti-Cold Shock Domain Containing E1, RNA-Binding (CDSE1) (Internal Region) antibody
CDSE1 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cold Shock Domain Containing E1, RNA-Binding (CDSE1) (AA 433-630) antibodyCDSE1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cold Shock Domain Containing E1, RNA-Binding (CDSE1) (AA 670-765) antibodyCDSE1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cold Shock Domain Containing E1, RNA-Binding (CDSE1) (AA 369-600) antibodyCDSE1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cold Shock Domain Containing E1, RNA-Binding (CDSE1) (AA 1-245) antibodyCDSE1 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cold Shock Domain Containing E1, RNA-Binding (CDSE1) (AA 1-767) antibodyCDSE1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chang, T.-C., Yamashita, A., Chen, C.-Y. A., Yamashita, Y., Zhu, W., Durdan, S., Kahvejian, A., Sonenberg, N., Shyu, A.-B. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. Genes Dev. 18: 2010-2023, 2004. 2. Doniger, J., DiPaolo, J. A. Coordinate N-RAS mRNA up-regulation with mutational activation in tumorigenic guinea pig cells. Nucleic Acids Res. 16: 969-980, 1988. 3. Edwards, M. C., Liegeois, N., Horecka, J., DePinho, R. A., Sprague, G. F., Jr., Tyers, M., Elledge, S. J. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Genetics 147: 1063-1076, 1997. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))
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别名
- CSDE1
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背景
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Synonyms: Sodium- and chloride-dependent GABA transporter 1,GAT-1,Solute carrier family 6 member 1,SLC6A1,GABATR, GABT1, GAT1,
Tissue Specificity: Expressed in many tissues, highest levels in skeletal muscle.
Background: Cold shock domain-containing protein E1 is a protein that in humans is encoded by the CSDE1 gene. Originally described as the product of an active transcription unit located upstream of the N-RAS gene, CSDE1 (cold shock domain-containing protein E1) is a highly conserved RNA-binding protein containing five cold-shock domains. CSDE1 is mostly localized in the cytoplasm where it interacts with distinct protein complexes involved in the post-transcriptional regulation of numerous mRNAs in a dynamic and complex manner. CSDE1 plays a role in maintaining the undifferentiated state of human embryonic stem cells (hESCs), and its loss results in accelerated neural differentiation and neurogenesis, partially via post-transcriptional regulation of fatty acid binding protein 7 (FABP7) and vimentin (VIM) mRNAs. In human melanoma, increased CSDE1 protein expression has been shown to modulate the levels of pro-oncogenic factors such as vimentin or RAC1 and tumor suppressors such as PTEN, thus promoting tumor invasion and metastasis.
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分子量
- 89 kDa
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基因ID
- 7812
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UniProt
- O75534
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途径
- SARS-CoV-2 Protein Interactome
抗原
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