TP53I3 抗体 (AA 1-332)
Quick Overview for TP53I3 抗体 (AA 1-332) (ABIN7599280)
抗原
See all TP53I3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-332
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原理
- Anti-PIG3/TP53I3 Antibody Picoband®
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-PIG3/TP53I3 Antibody Picoband® (ABIN7599280). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PIG3/TP53I3 recombinant protein (Position: M1-Q332).
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亚型
- IgG
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 1-2 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Contente, A., Dittmer, A., Koch, M. C., Roth, J., Dobbelstein, M. A polymorphic microsatellite that mediates induction of PIG3 by p53. Nature Genet. 30: 315-320, 2002. 2. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., Vogelstein, B. A model for p53-induced apoptosis. Nature 389: 300-305, 1997. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))
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别名
- TP53I3
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背景
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Synonyms: Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989
Background: Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene. The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats ly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
- 36 kDa
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基因ID
- 9540
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途径
- p53 Pathway
抗原
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