GRB10 抗体 (AA 1-251)
Quick Overview for GRB10 抗体 (AA 1-251) (ABIN7599161)
抗原
See all GRB10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-251
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原理
- Anti-GRB10 Antibody Picoband® (monoclonal, 5H7)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GRB10 Antibody Picoband® (monoclonal, 5H7) (ABIN7599161). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Monkey, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GRB10 recombinant protein (Position: M1-K251).
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亚型
- IgG1
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anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 392-594) antibody
GRB10 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 61-150) antibodyGRB10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (Ser428) antibodyGRB10 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 1-100) antibodyGRB10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (N-Term) antibodyGRB10 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 33-82) antibodyGRB10 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 1-536) antibodyGRB10 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 61-150) antibodyGRB10 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (Internal Region) antibodyVerified GRB10 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (pTyr67) antibodyGRB10 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Monkey, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Arnaud, P., Monk, D., Hitchins, M., Gordon, E., Dean, W., Beechey, C. V., Peters, J., Craigen, W., Preece, M., Stanier, P., Moore, G. E., Kelsey, G.Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark.Hum. Molec. Genet. 12: 1005-1019, 2003. 2. Charalambous, M., Smith, F. M., Bennett, W. R., Crew, T. E., Mackenzie, F., Ward, A.Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.Proc. Nat. Acad. Sci. 100: 8292-8297, 2003. 3. Frantz, J. D., Giorgetti-Peraldi, S., Ottinger, E. A., Shoelson, S. E.Human GRB-IR-beta/GRB10: splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.J. Biol. Chem. 272: 2659-2667, 1997. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))
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别名
- GRB10
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背景
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Synonyms: Deoxycytidine kinase, dCK, DCK
Tissue Specificity: Expressed ubiquitously in normal tissues.
Background: GRB10, Growth factor receptor-bound protein 10, also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.
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分子量
- 67 kDa
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基因ID
- 2887
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UniProt
- Q13322
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途径
- Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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