TMPRSS2 抗体 (AA 2-50)
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北京 101111
Quick Overview for TMPRSS2 抗体 (AA 2-50) (ABIN7595311)
抗原
See all TMPRSS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-50
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原理
- Guinea pig antibody to TMPRSS2
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特异性
- Specific for TMPRSS2.
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交叉反应
- 人, 大鼠
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交叉反应 （详细）
- Other species not yet test.
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纯化方法
- Whole serum
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免疫原
- A synthetic peptide from AA 2-50 of human TMPRSS2 conjugated to blue carrier protein was used as the antigen.
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anti-Transmembrane Protease, serine 2 (TMPRSS2) (AA 140-400) antibody
TMPRSS2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) (AA 284-492) antibodyTMPRSS2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) (Internal Region) antibodyVerified TMPRSS2 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) (AA 254-490) antibodyTMPRSS2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) antibodyTMPRSS2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) (AA 383-492) antibodyTMPRSS2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) (AA 1-30), (N-Term) antibodyTMPRSS2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18784 unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) (AA 1-492) antibodyTMPRSS2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Transmembrane Protease, serine 2 (TMPRSS2) (AA 314-343) antibodyTMPRSS2 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB18785 unconjugated
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应用备注
- IHC WB. A dilution of 1: 2000 is recommended fro WB,IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
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有效期
- 12 months
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- TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))
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别名
- TMPRSS2
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背景
- Function: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia. (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms proteolytic cleavage of ACE2 receptor which promotes viral uptake and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV) human metapneumovirus (HMPV) human parainfluenza 1 2 3 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1 H3N2 and H7N9), involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. Expression: Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon stomach and salivary gland. Coexpressed with ACE2 within lung type II pneumocytes ileal absorptive enterocytes intestinal epithelial cells cornea gallbladder and nasal goblet secretory cells
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途径
- SARS-CoV-2 Protein Interactome
抗原
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