OLIG2 抗体
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北京 101111
Quick Overview for OLIG2 抗体 (ABIN7595310)
抗原
See all OLIG2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Guinea pig antibody to Olig2
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特异性
- Specific for Olig2.
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交叉反应
- 小鼠, 大鼠
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交叉反应 (详细)
- Other species not yet tested.
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纯化方法
- Whole serum
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免疫原
- A synthetic peptide from mouse Olig2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
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应用备注
- IHC WB Flow Cyt. A dilution of 1 : 500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
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有效期
- 12 months
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- OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))
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别名
- Olig2
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背景
- Function: Required for oligodendrocyte and motor neuron specification in the spinal cord as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. Subcellular location: Nucleus. Cytoplasm Tissue specificity: Expressed in the brain in oligodendrocytes. Strongly expressed in oligodendrogliomas while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. Involvement in disease: A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14,21)(q11.2,q22) with TCRA.
抗原
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