Prostacyclin Receptor 抗体 (3rd Extracellular Loop) (FITC)
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Quick Overview for Prostacyclin Receptor 抗体 (3rd Extracellular Loop) (FITC) (ABIN7582070)
抗原
See all Prostacyclin Receptor (PTGIR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 3rd Extracellular Loop, AA 290-302
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原理
- A Rabbit Polyclonal Antibody to PTGIR (extracellular) conjugated to the fluorescent dye FITC
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序列
- (C)TQAIAPDSRE MGD
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预测反应
- Mouse - identical, human - 11,13 amino acid residues identical
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产品特性
- Anti-Prostacyclin Receptor (PTGIR) (extracellular) Antibody (ABIN7043563, ABIN7045122 and ABIN7045123) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot and live cell flow cytometry applications. It has been designed to recognize PGI2 from mouse, rat and human samples. Anti-Prostacyclin Receptor (PTGIR) (extracellular)-FITC Antibody (ABIN7043563, ABIN7045122 and ABIN7045123-F) is directly conjugated to fluorescein isothiocyanate (FITC) fluorophore. This conjugated antibody has been developed to be used in immunofluorescent applications such as direct flow cytometry and live cell imaging. It has been designed to recognize PGI2 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)TQAIAPDSREMGD, corresponding to amino acid residues 290-302 of rat PTGIR
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亚型
- IgG
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anti-Prostacyclin Receptor (PTGIR) (AA 207-386) antibody
PTGIR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) (AA 296-386) antibodyPTGIR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Prostacyclin Receptor (PTGIR) (AA 296-387) antibodyPTGIR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Prostacyclin Receptor (PTGIR) antibodyPTGIR 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) (3rd Extracellular Loop), (AA 290-302) antibodyPTGIR 适用: 大鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) antibodyPTGIR 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) (N-Term) antibodyPTGIR 适用: 人, 猴, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) antibodyPTGIR 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) antibodyPTGIR 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) (AA 198-247) antibodyPTGIR 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: The optimal concentration should be determined by the user
FC: 2.5-5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7236620)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 15 μL or 50 μL double distilled water (DDW), depending on the sample size.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Prostacyclin Receptor (PTGIR)
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别名
- PTGIR
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背景
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Synonyms: Prostanoid IP receptor, Prostaglandin I2 receptor, PGI2 receptor, PRIPR
Description: Prostaglandins comprise a family of locally acting hormones, whose synthesis is initiated by the enzyme COX. This pathway is involved in a broad variety of pathological conditions such as cancer, inflammation and hypertension.Prostaglandin I2 receptor (PGI2 receptor) is G-coupled protein receptor (GPCR) with seven hydrophobic transmembrane segments and an extracellular NH2 terminus. Prostaglandin receptors belong to family A, group V of GPCRs. There is significant ligand-binding cross-reactivity between different prostaglandins and different receptors in the family. Within the PG family, receptors share roughly 20-30 % of their sequence and there are 34 identical residues across the family. Twenty of these residues are unique to PG receptors and are not shared by other GPCRs. The unique residues reside mostly in the transmembrane region and in the second extracellular loop region. Both of these regions are implicated in ligand binding. The PGI2 receptor signals primarily via stimulation of cAMP generation but through PIP2 as well despite a much higher agonist concentration required for PIP2 hydrolysis.PGI2 receptor mRNA is highly expressed in the human heart, aorta, kidney, liver and lung tissues and in mice thymus, heart and spleen1. Mice lacking PGI2 receptor have been shown to have a reduced inflammation response and a significant decrease in clinical arthritis. In addition, human patients with a dysfunctional PGI2 receptor variant exhibit an enhanced atherothrombotic phenotype with higher incidence of triple vessel coronary disease and cardiovascular events2.
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基因ID
- 292661
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UniProt
- P43253
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途径
- cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling
抗原
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