SLC3A2 抗体 (Extracellular)
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Quick Overview for SLC3A2 抗体 (Extracellular) (ABIN7581980)
抗原
See all SLC3A2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 150-164, Extracellular
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原理
- A Rabbit Polyclonal antibody to CALHM2 (extracellular)
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序列
- (C)KGLVLGPIHK NQKDE
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特异性
- Extracellular, C-terminus.
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预测反应
- Rat - identical Human - 14 out of 15 amino acid residues identical
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产品特性
- Anti-SLC3A2 (CD98) (extracellular) Antibody (ABIN7581980) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize SLC3A2 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KGLVLGPIHKNQKDE, corresponding to amino acid residues 150 - 164 of mouse SLC3A2
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亚型
- IgG
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anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 1-529) antibody
SLC3A2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) antibodySLC3A2 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 360-529) antibodySLC3A2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 231-280) antibodySLC3A2 适用: 人, 大鼠, Pig WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 213-349) antibodySLC3A2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) antibody (Biotin)SLC3A2 适用: 人 FACS, IP, IHC (p) 宿主: 小鼠 Monoclonal MEM-108 Biotin
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) antibody (FITC)SLC3A2 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-108 FITC
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 588-615), (C-Term) antibodySLC3A2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22529 unconjugated
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 285-521) antibodySLC3A2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) antibodySLC3A2 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal H202-529-4-1-4 unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200-1:400
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SLC3A2 (Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2))
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别名
- SLC3A2
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背景
- Solute Carrier Family 3 Member 2, 4F2 Cell-Surface Antigen Heavy Chain, 4F2HC, CD98 Antigen Heavy Chain, CD98HC,Solute carrier family 3 member 2 (SLC3A2), also known as 4F2 cell-surface antigen heavy chain (4F2HC) and CD98 antigen heavy chain (CD98hc), is a type II membrane protein belonging to the SLC3A/CD98 transporter family that plays a role in various physiological processes including amino acid transport, cell differentiation, migration, and proliferation.1,2,4SLC3A2 is a type II glycosylated protein composed of an extracellular domain, a transmembrane domain, and a cytoplasmic domain. SLC3A2 forms obligatory heterodimeric complexes with six members of the L-type amino acid transporters (LATs) SLC7A5-11, and SLC7A13.1The heteromeric complex between SLC3A2 and SLC7A5 (also known as LAT1) is one of the best characterized. SLC7A5 is responsible for the transport of large neutral amino acids, including leucine, across the cell membrane. SLC3A2 acts as a chaperone protein for SLC7A5, stabilizing its expression on the cell surface and assisting in its proper functioning. This partnership is essential for amino acid transport, cell growth, and protein synthesis. This complex is particularly important in cancer cells and immune cells, as it facilitates nutrient uptake and influences cell proliferation and immune responses.1-4In addition to SLC7A5, SLC3A2 also forms a complex with another SLC7 family member called SLC7A11 (also known as xCT). This complex is commonly referred to as the CD98/xCT or SLC3A2/SLC7A11.1-4xCT, is a cystine/glutamate antiporter that plays a crucial role in the cellular exchange of cystine (an amino acid involved in the synthesis of the antioxidant glutathione) for glutamate. This exchange is important for maintaining cellular redox balance and protecting cells from oxidative stress.1,3,5When SLC3A2 partners with SLC7A11, it facilitates the function of the xCT antiporter, allowing cells to import cystine while exporting glutamate. This process is essential for antioxidant defence and protecting cells from damage caused by reactive oxygen species (ROS). The SLC3A2/SLC7A11 complex has significant implications in cancer biology and the modulation of immune responses, as it can influence cellular redox status and affect processes related to cell proliferation and immune cell function.1,3,5
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基因ID
- 17254
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UniProt
- P10852
抗原
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