Neurotrophin 3 抗体 (Pro-Domain)
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Quick Overview for Neurotrophin 3 抗体 (Pro-Domain) (ABIN7886734)
抗原
See all Neurotrophin 3 (NTF3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 89-103, Pro-Domain
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原理
- A Rabbit Polyclonal Antibody to proNT-3
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序列
- (C)DTELLRQQRR YNSPR
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交叉反应 （详细）
- The antibody is specific for proNT-3, it does not crossreact with proNGF, proBDNF or mature NT-3.
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预测反应
- Rat,mouse - identical
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产品特性
- Highly specific antibody directed against an epitope of human pro. Anti-pro Antibody (ABIN7581927) can be used in western blot and immunohistochemistry applications. It has been designed to recognize pro from rat, mouse and human samples. The antibody does not cross reacts with mature , pro- and mature NGF or pro- and mature BDNF.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DTELLRQQRRYNSPR, corresponding to amino acid residues 89-103 of human NT-3 (precursor)
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亚型
- IgG
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anti-Neurotrophin 3 (NTF3) (AA 139-257) antibody
NTF3 适用: 人 WB, IHC, ICC, IHC (p), IF 宿主: 小鼠 Monoclonal 5A2 unconjugated
anti-Neurotrophin 3 (NTF3) (AA 152-184), (C-Term) antibodyNTF3 适用: 人, 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal RB14406 unconjugated
anti-Neurotrophin 3 (NTF3) (AA 19-100) antibodyNTF3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophin 3 (NTF3) (AA 19-257) antibodyNTF3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophin 3 (NTF3) (AA 130-255) antibodyNTF3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Neurotrophin 3 (NTF3) (AA 1-257) antibodyNTF3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophin 3 (NTF3) (N-Term) antibodyNTF3 适用: 人, 小鼠, 大鼠, Cow, 犬, Hamster, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophin 3 (NTF3) (AA 130-255) antibodyNTF3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophin 3 (NTF3) (AA 122-151) antibodyNTF3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14463 unconjugated
anti-Neurotrophin 3 (NTF3) (AA 174-189), (Middle Region) antibodyNTF3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:300-1:600
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neurotrophin 3 (NTF3)
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别名
- NTF3
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背景
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Synonyms: pro-Neurotrophin 3, proNTF3
Description: Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5).All neurotrophins are synthesized as preproneurotrophin precursors that are subsequently processed within the intracellular transport pathway to yield proneurotrophins. These are further processed to generate the mature form. The mature form of BDNF is a non-covalent stable homodimer that can be secreted in both constitutive and regulated pathways.Until recently, the functional role of the neurotrophin prodomain was thought to assist in the correct folding of the mature protein and the sorting of the neurotrophin into the constitutive or regulated secretory pathway. However, a growing body of evidence suggests that the uncleaved proneurotrophin precursors can be secreted from cells and that they may mediate different biological functions. Several studies implicate both proNGF and proBDNF in several physiological and pathological conditions.It remains to be established whether proNT-3 has different biological functions than the mature NT-3 neurotrophin.
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基因ID
- 4908
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UniProt
- P20783
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途径
- RTK signaling, Neurotrophin Signaling Pathway
抗原
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