CNR1 抗体 (Extracellular, N-Term)
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Quick Overview for CNR1 抗体 (Extracellular, N-Term) (ABIN7581863)
抗原
See all CNR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 84-99, Extracellular, N-Term
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原理
- A Guinea Pig Polyclonal Antibody to Cannabinoid Receptor 1 (extracellular)
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序列
- NKSLSSFKEN EENIQC
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预测反应
- Human - identical, mouse - 15,16 amino acid residues identical
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产品特性
- Guinea Pig Anti-Cannabinoid Receptor 1 (extracellular) Antibody (ABIN7581863) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CB1R from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-Cannabinoid Receptor 1 (extracellular) Antibody (ABIN7043023, ABIN7044155 and ABIN7044156) raised in rabbits. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- NKSLSSFKENEENIQC, corresponding to amino acid residues 84-99 of rat CB1 receptor
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亚型
- IgG
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anti-Cannabinoid Receptor 1 (CNR1) (C-Term) antibody
CNR1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (Internal Region) antibodyVerified CNR1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (N-Term) antibodyCNR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-110) antibodyCNR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F9 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-110) antibodyCNR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 73-122) antibodyCNR1 适用: 人, 大鼠, 猴, Cow, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (C-Term) antibodyCNR1 适用: 人, 大鼠, 小鼠, 猴, 犬, Cow, 马, Bat, Pig IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) antibodyMicroarray verified CNR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB313026 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-75) antibodyCNR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 84-99), (Extracellular), (N-Term) antibodyCNR1 适用: 大鼠 WB, IHC, IF, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235028)
Blocking Peptide: (ABIN7235028)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CNR1 (Cannabinoid Receptor 1 (CNR1))
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别名
- CNR1
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背景
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Synonyms: CB1, CB-R, CB1R, CANN6, Brain-type cannabinoid receptor, Central cannabinoid receptor, CNR1
Description: Cannabinoids have been used in Eastern medicine for many years as pain relievers.1 Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two specific cannabinoid receptors: cannabinoid receptor 1 (CB1 receptor) and cannabinoid receptor 2 (CB2 receptor).2 The cannabinoid receptors can be distinguished by their amino acid sequences, signaling mechanisms, and tissue distributions.2 Both receptors belong to the G-protein coupled receptor (GPCR) superfamily. CB1 was shown to modulate several Ca2+ and K+ ion channels.2,3CB1 is primarily expressed in the central nervous system. However, expression of CB1 is also detected in the peripheral terminals, in non-neuronal peripheral tissues such as uterus, testes, spleen, as well as in cells of the immune system.3,4CB1 is implicated in many cellular functions such as neurotransmitter release, pain relief, cancer, and obesity.5,6 Growth inhibition of tumor cells was demonstrated following mixed CB1/CB2 agonist treatment in both prostate and non-melanoma skin cancers.5,6 Through their interaction with CB1, cannabinoid compounds stimulate appetite for sweets and palatable foods in particular, making CB1 an attractive therapeutic target for the treatment of obesity and eating disorders.7
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基因ID
- 25248
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UniProt
- P20272
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途径
- Feeding Behaviour
抗原
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