CNR1 抗体 (N-Term)
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- 抗原 See all CNR1 抗体
- CNR1 (Cannabinoid Receptor 1 (CNR1))
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抗原表位
- N-Term
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CNR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- CNR1 Antibody detects endogenous levels of total CNR1.
- 预测反应
- Bovine,Horse,Sheep,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CNR1, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CNR1 Primary Antibody
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anti-Cannabinoid Receptor 1 (CNR1) (C-Term) antibody
CNR1 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (Internal Region) antibodyVerified CNR1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (C-Term) antibodyCNR1 适用: 人, 大鼠, 小鼠, 猴, 犬, 马, Cow, Pig, Bat IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) antibodyMicroarray verified CNR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB313026 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-110) antibodyCNR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F9 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-110) antibodyCNR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 73-122) antibodyCNR1 适用: 人, 大鼠, 猴, Cow, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 84-99), (Extracellular), (N-Term) antibodyCNR1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-117) antibodyCNR1 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-110) antibodyCNR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CNR1 (Cannabinoid Receptor 1 (CNR1))
- 别名
- CNR1 (CNR1 产品)
- 别名
- CANN6 antibody, CB-R antibody, CB1 antibody, CB1A antibody, CB1K5 antibody, CB1R antibody, CNR antibody, SKR6R antibody, cnr1-A antibody, cannabinoid receptor 1 antibody, cannabinoid receptor 1 (brain) antibody, cannabinoid receptor 1 (brain) S homeolog antibody, CNR1 antibody, Cnr1 antibody, cnr1 antibody, cnr1.S antibody
- 背景
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Description: G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta9-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca2+ channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca2+ channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a proinflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712).
Gene: CNR1
- 分子量
- 53 kDa
- 基因ID
- 1268
- UniProt
- P21554
- 途径
- Feeding Behaviour
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