BDKRB1 抗体 (Extracellular)
Quick Overview for BDKRB1 抗体 (Extracellular) (ABIN7581830)
抗原
See all BDKRB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 202-214, Extracellular
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原理
- A Rabbit Polyclonal Antibody to B1 Bradykinin Receptor
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序列
- (C)HEAWHFVRMV ELN
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特异性
- Extracellular, 2nd loop.
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预测反应
- Rat - 12 out of 13 amino acid residues identical Not recommended for human samples
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产品特性
- Anti-B1 Bradykinin Receptor (BDKRB1) (extracellular) Antibody (ABIN7581830) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and indirect flow cytometry applications. It has been designed to recognize B1 Bradykinin Receptor from mouse and rat samples. The antibody won't recognize human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HEAWHFVRMVELN, corresponding to amino acid residues 202 - 214 of mouse BDKRB1
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亚型
- IgG
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anti-Bradykinin Receptor B1 (BDKRB1) (AA 1-100) antibody
BDKRB1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 161-260) antibodyBDKRB1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (Cytoplasmic Domain) antibodyBDKRB1 适用: 人 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (Extracellular Domain) antibodyBDKRB1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (C-Term) antibodyBDKRB1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 1-353) antibodyBDKRB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A2 unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (Internal Region) antibodyVerified BDKRB1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 1-353) antibodyBDKRB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 1-353) antibodyBDKRB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 230-279) antibodyBDKRB1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400-1:500
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- BDKRB1 (Bradykinin Receptor B1 (BDKRB1))
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别名
- BDKRB1
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背景
- BK-1 receptor, BKRB1, B1R, BKR1,Kinins are small peptides rapidly produced following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) appear to initiate a similar cascade of events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function.1Kinins such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2). The desArg9-BK and Lys-desArg9-BK peptides activate BKRB1 while BK and Lys-BK operate by activating BKRB2.2 Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Expression of BKRB1is inducible upon various types of tissue injury and by inflammatory mediators such as bacterial lipopolysaccharide (LPS) and cytokines. BKRB1 was long considered not to be expressed in healthy tissues. However, recent work has demonstrated a low level of expression of BKRB1 in the CNS of rodent and primates. In contrast, BKRB2 is constitutively expressed on various cell types.3 BKRB1 represents a potential therapeutic target for treatment of inflammatory disorders and cardiovascular diseases.
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基因ID
- 12061
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UniProt
- Q61125
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途径
- ACE Inhibitor Pathway
抗原
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