ADORA1 抗体 (Extracellular)
Quick Overview for ADORA1 抗体 (Extracellular) (ABIN7581822)
抗原
See all ADORA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 153-168, Extracellular
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原理
- A Rabbit Polyclonal antibody to Adenosine A1 Receptor (extracellular)
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序列
- (C)EQDWRANGSV GEPVIK
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特异性
- Extracellular, 2nd loop.
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预测反应
- Mouse - 14 out of 16 amino acid residues identical Not recommended for human samples
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产品特性
- Anti-Adenosine A1 Receptor (extracellular) Antibody (ABIN7581822) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize Adenosine A1 Receptor from mouse and rat samples. This antibody is not recommended for human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EQDWRANGSVGEPVIK, corresponding to amino acid residues 153 - 168 of rat Adenosine A1 Receptor
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亚型
- IgG
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anti-Adenosine A1 Receptor (ADORA1) antibody
ADORA1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 225-326) antibodyADORA1 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 213-229) antibodyKO Validated ADORA1 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) antibodyADORA1 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 10D12 unconjugated Recombinant Antibody
anti-Adenosine A1 Receptor (ADORA1) (Asp326) antibodyADORA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (C-Term) antibodyVerified ADORA1 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (C-Term) antibodyADORA1 适用: 人, 大鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 151-250) antibodyADORA1 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 202-235) antibodyADORA1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (C-Term) antibodyADORA1 适用: 人, 大鼠 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200-1:400
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- ADORA1 (Adenosine A1 Receptor (ADORA1))
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别名
- ADORA1
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背景
- Adenosine Receptor A1, Adenosine A1R, ADORA1,Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including the brain and heart.1,2 Adenosine exerts its actions via four specific adenosine receptors (also named P1 purinergic receptors): Adenosine A1 Receptor (A1AR), Adenosine A2A Receptor (A2AAR), Adenosine A2B Receptor (A2BAR), and Adenosine A3 Receptor (A3AR). All are integral membrane proteins and are members of the G protein-coupled receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important for binding G proteins.1-3 The adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs.1-3A1AR is widely distributed and has been well characterized. High expression of A1AR is found in the brain (mainly in the cortex, cerebellum, and hippocampus), dorsal horn of the spinal cord, adrenal gland, and atria, and to a lower extent in several other tissues including adipose tissue, the colon, and kidney.2,4A1AR modulates the activity of several ion channels. Activation of A1AR (by adenosine, its major agonist) inhibits N-type Ca2+ channels via a voltage-dependent, pertussis toxin (PTX)-sensitive pathway in neurons of the rat major pelvic ganglia (MPG).5Since A1AR is the most prominent adenosine receptor in adipocytes, it has become a natural target for research on obesity, which is a major health problem.6,7 A possible role in cell proliferation and carcinogenesis has also been suggested for A1AR.8,9
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基因ID
- 29290
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UniProt
- P25099
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途径
- EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Synaptic Membrane
抗原
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