LPHN3 抗体 (AA 572-586)
-
- 抗原 See all LPHN3 抗体
- LPHN3 (Latrophilin 3 (LPHN3))
-
抗原表位
- AA 572-586
-
适用
- 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This LPHN3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to Latrophilin-3
- 序列
- (C)REIMWFKTRQ GQVAK
- 预测反应
- Rat - identical,Human- 14,15 identical
- 产品特性
- Anti-Latrophilin-3 (extracellular) Antibody (ABIN7581821) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Latrophilin-3 from mouse, rat and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
- (C)REIMWFKTRQGQVAK, corresponding to amino acid residues 572 - 586 of mouse Latrophilin-3
- 亚型
- IgG
- Top Product
- Discover our top product LPHN3 Primary Antibody
-
anti-Latrophilin 3 (LPHN3) (AA 1105-1447) antibody
LPHN3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (C-Term) antibodyLPHN3 适用: 人, 小鼠, 大鼠, 小鸡, 马, 猴, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (C-Term) antibodyLPHN3 适用: 人, 小鼠, 大鼠, 小鸡, 马, 猴, Bat, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (AA 371-397), (N-Term) antibodyLPHN3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB36957 unconjugated
anti-Latrophilin 3 (LPHN3) (C-Term) antibodyLPHN3 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (Cytoplasmic Domain) antibodyLPHN3 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Antigen preadsorption control: 1 μg peptide per 1 μg antibody
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
- 抗原
- LPHN3 (Latrophilin 3 (LPHN3))
- 别名
- ADGRL3 (LPHN3 产品)
- 背景
- Adhesion G Protein-Coupled Receptor L3, ADGRL3, Calcium-Independent Alpha-Latrotoxin Receptor 3, LPHN3, Lectomedin-3,Latrophilin-3 (LPHN3), also known as ADGRL3, is a member of the adhesion G-protein-coupled receptor (aGPCR) family. This family is characterized by the presence of a GPCR autoproteolysis-inducing (GAIN) domain that facilitates receptor cleavage and activation, along with seven transmembrane domains1,3. LPHN3 is primarily localized to the cell membrane and is prominently expressed in neurons, with high levels observed in brain regions such as the hippocampus and prefrontal cortex1,5. LPHN3 plays critical roles in neuronal development and synapse formation. It mediates its effects through dual mechanisms: coupling with intracellular G-proteins, particularly Gαs and Gα12/13, and recruiting phase-separated postsynaptic protein scaffolds. Activation of LPHN3 is triggered by interactions with its ligands, such as teneurins and FLRTs, which enhance synaptic clustering by promoting scaffold protein condensates. Alternative splicing of Lphn3, studied in mouse models, modulates these pathways, influencing synaptic connectivity and neuronal activity3,4. Biologically, LPHN3 is involved in attention regulation and motor control, with its dysregulation linked to attention deficit hyperactivity disorder (ADHD). Genetic variants in LPHN3 are associated with altered dopaminergic signaling and increased susceptibility to ADHD, as demonstrated in human studies1,2. Furthermore, LPHN3 dysfunction has been implicated in substance use disorders and learning deficits, underscoring its importance in neuropsychiatric and cognitive processes2,5.
- 基因ID
- 319387
- UniProt
- Q80TS3
-
