我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

RAGE 抗体 (AA 151-250)

Name: RAGE 抗体 (AA 151-250)
SKU: ABIN725900
Availability: OutOfStock

Cited in 5+ publications. This anti-RAGE antibody is a 兔多克隆 antibody detecting RAGE in WB, ELISA, IP, ICC, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 人, 小鼠和大鼠.

Raji Cells lysates probed with RAGE Polyclonal Antibody, unconjugated at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 60 minutes at 37°C. (RAGE 抗体 (AA 151-250))

Formalin-fixed and paraffin embedded: rat sciatic nerve labeled with Anti-AGER/RAGE Polyclonal Antibody, Unconjugated (ABIN725900) at 1:200 followed by conjugation to the secondary antibody and DAB staining (RAGE 抗体 (AA 151-250))

IHC

NIH/3T3 cells probed with Rabbit Anti-RAGE Polyclonal Antibody Alexa Fluor 488 Conjugated Secondary Antibody. (RAGE 抗体 (AA 151-250))

FACS

Formalin-fixed and paraffin embedded: rat sciatic nerve labeled with Anti-AGER/RAGE Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (RAGE 抗体 (AA 151-250))

IHC (p)

4 images

(5 references)

产品编号 ABIN725900

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for RAGE 抗体 (AA 151-250) (ABIN725900)

抗原

See all RAGE (AGER) 抗体

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This RAGE antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product AGER Primary Antibody

抗原表位
16

16

15

11

9

9

8

7

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 151-250

交叉反应

人, 小鼠, 大鼠

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from rat AGER

亚型

IgG
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 180-402) antibody
AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-237) antibody
AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-404) antibody
AGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-274) antibody
AGER 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) antibody
AGER 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C1 unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-120), (N-Term) antibody
AGER 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 76-104) antibody
AGER 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) antibody (Cy3)
AGER 适用: 人, Cow WB, IHC, ELISA, ICC, IHC (p) 宿主: 小鼠 Monoclonal DD-A11 Cy3

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 173-418) antibody
AGER 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (N-Term) antibody
AGER 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg)
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Fu, Shi, Song, Liu, Wang, Wang, Song, Song: "From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 153, Issue 2, pp. 303-15, (2016) (PubMed).

Sun, Liu, Xue, Wang: "Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats." in: Journal of neuroscience research, Vol. 93, Issue 4, pp. 666-77, (2015) (PubMed).

Zhu, Yao, Zhang, Dong, Yu, Sheng: "Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function." in: Acta pharmacologica Sinica, Vol. 35, Issue 9, pp. 1167-76, (2014) (PubMed).

Yu, Wu, Cai, Xiang, Zha, Fan, Guo, Ming, Liu: "Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats." in: PLoS ONE, Vol. 7, Issue 12, pp. e52013, (2012) (PubMed).

Huang, Yao, Zhang, Dong, Yu, Sheng: "The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats." in: Shock (Augusta, Ga.), Vol. 31, Issue 3, pp. 322-9, (2009) (PubMed).
抗原

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

别名

RAGE

背景

Synonyms: RAGE, Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, Ager
Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

基因ID

81722

UniProt

Q63495

途径

Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins