PD-1 抗体
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北京 101111
Quick Overview for PD-1 抗体 (ABIN7566443)
抗原
See all PD-1 (PDCD1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-PD-1 (human), mAb (AG-IHC001)
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产品特性
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Monoclonal Antibody. Recognizes human PD-1 (CD279). Applications: ELISA, IHC. Isotype: Mouse IgG2b. Clone: AG-IHC001. Liquid. In Tris Buffer, pH 7.4, containing 1 % BSA and <0.1 % sodium azide. Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T cell regulators, expressed as a co-receptor on the surface of activated T cells, B cells and macrophages. Several studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to antitumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non-small-cell lung cancer, melanoma and renal-cell cancer. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).
Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T cell regulators, expressed as a co-receptor on the surface of activated T cells, B cells and macrophages. Several studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to antitumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non-small-cell lung cancer, melanoma and renal-cell cancer. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).
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纯化方法
- Protein A/G purified.
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免疫原
- Recombinant human PD-1 fused to a His-tag.
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亚型
- IgG2b
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anti-Programmed Cell Death 1 (PDCD1) (AA 201-288) antibody
PDCD1 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 3B3D9 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8G5B12 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 1D6F6 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 3E12A10 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 1-288) antibodyPDCD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) antibodyPDCD1 适用: 人 IHC, ELISA, StM, Coat 宿主: 小鼠 Monoclonal PDCD1-2720 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C3 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In Tris Buffer, pH 7.4, containing 1 % BSA and <0.1 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
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Stable for at least 1 year after receipt when stored at +4°C.
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- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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别名
- PD-1
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UniProt
- Q15116
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途径
- Cancer Immune Checkpoints
抗原
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