Recombinant CRHR2 抗体
Quick Overview for Recombinant CRHR2 抗体 (ABIN7566415)
抗原
See all CRHR2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
 - anti-Crf2 (Aspergillus fumigatus), mAb (rec.) (MS112-IIA1)
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产品特性
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Recombinant Antibody. Recognizes Crf2 from Aspergillus fumigatus. Possible cross-reactivity with Crf1, Crf2 and Asp f9 [Reference 2]. Applications: ELISA, FUNC, IHC, WB, IF. Clone: MS112-IIA1. Isotype: Human IgG1. Formulation: Liquid. In PBS. Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires an early and specific diagnosis of IA. Encoded by CRF1 gene, the Crf protein family contains three protein variants: Crf2 protein, amino acids (333 aa) long, Asp f9 protein (292 aa), first identified as an allergen using serum from Aspergillus-allergic patients and Crf1 (395 aa, also named Crh5). The glycosyol hydrolase/glycosidase Crf2 catalyzes the hydrolysis of glycosidic bonds in complex sugars and is located in the cell wall of the growing hyphae. Crf2 may be involved in the remodeling of the cell wall as well, and therefore in the growth and the virulence of the fungus.
Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires an early and specific diagnosis of IA. Encoded by CRF1 gene, the Crf protein family contains three protein variants: Crf2 protein, amino acids (333 aa) long, Asp f9 protein (292 aa), first identified as an allergen using serum from Aspergillus-allergic patients and Crf1 (395 aa, also named Crh5). The glycosyol hydrolase/glycosidase Crf2 catalyzes the hydrolysis of glycosidic bonds in complex sugars and is located in the cell wall of the growing hyphae. Crf2 may be involved in the remodeling of the cell wall as well, and therefore in the growth and the virulence of the fungus.
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纯化方法
 - Puified
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纯度
 - >95 % (SDS-PAGE)
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免疫原
 - Recombinant Crf2 (Aspergillus fumigatus) containing a C-terminal His-tag.
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亚型
 - IgG1
 
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应用备注
 - Optimal working dilution should be determined by the investigator.
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 mg/mL
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缓冲液
 - In PBS.
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注意事项
 - After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.Please handle under sterile conditions to avoid contamination.
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储存条件
 - 4 °C,-20 °C
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储存方法
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Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 1 week when stored at +4°C.
 
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- CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))
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别名
 - Crf2
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UniProt
 - Q4WI46
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途径
 - Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour
 
抗原
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