ACE2 抗体
Quick Overview for ACE2 抗体 (ABIN7566406)
抗原
See all ACE2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-ACE2 (human), mAb (blocking) (AC384) (preservative free)
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产品特性
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Monoclonal Antibody. Recognizes human ACE2. Application: ELISA, WB, FUNC (Blocking). Clone: AC384. Isotype: Mouse IgG1κ. Liquid. In PBS. Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin, that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
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免疫原
- Recombinant human ACE2.
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亚型
- IgG1 kappa
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anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 601-700) antibody
ACE2 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) antibodyACE2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal AC18F unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-250) antibodyACE2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 93-464) antibodyACE2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 392-739) antibodyACE2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (N-Term) antibodyVerified ACE2 适用: 人 WB, IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 773-805), (C-Term) antibodyACE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4819 unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 140-172) antibodyACE2 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 59-90) antibodyACE2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 351-450) antibodyACE2 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS.
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储存液
- Without preservative
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
Stable for at least 1 year after receipt when stored at -20°C.
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- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
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别名
- ACE2
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途径
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
抗原
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