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Recombinant K-RAS 抗体 (Glu12Asp Mutant)

Name: Recombinant K-RAS 抗体 (Glu12Asp Mutant)
Brand: antibodies-online
SKU: ABIN7543442
Availability: OutOfStock

This anti-K-RAS antibody is a 小鼠单克隆 antibody detecting K-RAS in ELISA. Suitable for 人.

产品编号 ABIN7543442

发货至: 中国

Datasheet as PDF

Quick Overview for Recombinant K-RAS 抗体 (Glu12Asp Mutant) (ABIN7543442)

抗原

See all K-RAS (KRAS) 抗体

K-RAS (KRAS) (GTPase Kras (KRAS))

抗体类型

Recombinant Antibody

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This K-RAS antibody is un-conjugated

应用范围

ELISA

克隆位点

D113

Discover our top product KRAS Primary Antibody

抗原表位
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10

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2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Glu12Asp Mutant

原理

Anti-KRAS G12D mutant [D113], Mouse IgG1, kappa

特异性

This antibody binds the G12D mutant form of human KRAS protein. This ras protein binds GDP/GTP and possess intrinsic GTPase activity, that results in conversion of nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). This protein plays an important role in many signal transduction pathways and regulation of cell proliferation. Somatic KRAS mutations are highly observed in leukemias, colorectal cancer, pancreatic cancer and lung cancer. KRAS mutation is G12D which is estimated to be present in up to 37 % pancreatic cancers and over 12 % of colorectal cancers.

产品特性

Original Species of Ab: Mouse
Original Format of Ab: IgG1

纯化方法

Protein A affinity purified

免疫原

The original antibody was generated by immunizing mice with a synthetic dodecapeptide 'KLVVVGADGVGK'.

亚型

IgG1 kappa
anti-GTPase Kras (KRAS) (AA 1-188) antibody
KRAS 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B10-2F2 unconjugated

anti-GTPase Kras (KRAS) (AA 16-125) antibody
KRAS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F3 unconjugated

anti-GTPase Kras (KRAS) (AA 146-174) antibody
KRAS 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-GTPase Kras (KRAS) (AA 25-130) antibody
KRAS 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-GTPase Kras (KRAS) (AA 2-168) antibody
KRAS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-GTPase Kras (KRAS) (N-Term) antibody
KRAS 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 兔, 马, 豚鼠, Cow, Drosophila melanogaster, Pig, Bat, 小鸡, 非洲爪蟾, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-GTPase Kras (KRAS) (pSer89) antibody
KRAS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-GTPase Kras (KRAS) (N-Term) antibody
KRAS 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 兔, 马, 豚鼠, Cow, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated

anti-GTPase Kras (KRAS) (AA 1-189) antibody
KRAS 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-GTPase Kras (KRAS) antibody
KRAS 适用: 人 WB 宿主: 小鼠 Monoclonal 2C1 unconjugated

应用备注

The binding reactivity and epitope characterization of this antibody towards human KRAS G12D mutant was determined using ELISA (PMID: 9440050). This antibody can bind both the peptide 'KLVVVGADGVGK' conjugated BSA as well as KRAS G12D mutant in an ELISA.

限制

仅限研究用
浓度

1 mg/mL

缓冲液

PBS with 0.02 % Proclin 300.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
抗原

K-RAS (KRAS) (GTPase Kras (KRAS))

别名

KRAS

背景

K-Ras, GTPase Kras, KRAS2, RASK2, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, ras p21 protein, p21 ras, D113-2-1

UniProt

P01116-2