Recombinant Keratin 5/6 抗体 (AA 488-590)
The 兔 Chimeric anti-Keratin 5/6 antibody is suitable to detect Keratin 5/6 in samples from 人. It has been validated for IHC 和 ELISA.
产品编号 ABIN7543311
发货至:
中国
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Quick Overview for Recombinant Keratin 5/6 抗体 (AA 488-590) (ABIN7543311)
抗原
Keratin 5/6 (KRT5/6)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
Chimeric
标记
This Keratin 5/6 antibody is un-conjugated
应用范围
Immunohistochemistry (IHC), ELISA
克隆位点
AbM58019-7H4
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抗原表位
- AA 488-590
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原理
- Anti-Cytokeratin 5/6 [AbM58019-7H4], Rabbit IgG, kappa
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特异性
- This antibody is capable of binding human cytokeratin 5 and human cytokeratin 6. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 5/6 is often expressed in a basal cell layer of normal mammary ducts. Studies have also shown that CK5/6 can be used as a characteristic marker of basal-like breast cancer.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2b
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing 4-6 weeks old female ICR mice with recombinant protein comprising amino acids 488-590 of cytokeratin 5 in equal volume of Freund's incomplete adjuvant.
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亚型
- IgG kappa
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anti-Keratin 5/6 (KRT5/6) (AA 548-564), (C-Term) antibody
KRT5/6 适用: 人 IHC (p) 宿主: 兔 Monoclonal T16-K unconjugated
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应用备注
- The binding characterization of this antibody was done using ELISA. The original IgG2b antibody binds cytokeratin 5/6 with a high affinity constant of 3.84 x 10^(9) M^(-1). This antibody was also used in the immunohistochemical analysis of esophagus and esophageal squamous cell carcinoma. The immunohistochemical staining pattern of this antibody is similar to commercially available antibody D5/16B4 (CN113845592).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Keratin 5/6 (KRT5/6)
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别名
- Cytokeratin 5/6
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背景
- CK5/6, CK5, CK-5, K5 KRT5, Keratin, type II cytoskeletal 5, cytokeratin-5, 58 kDa cytokeratin, Type-II keratin Kb5, CGMCC NO 21982, D5/16B4
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UniProt
- P13647
抗原
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