Recombinant p40 (p63 Delta) (AA 4-19) 抗体
This anti- antibody is a 小鼠 单克隆 antibody detecting in IHC 和 ELISA. Suitable for 人.
Quick Overview for Recombinant p40 (p63 Delta) (AA 4-19) 抗体 (ABIN7543297)
抗原
p40 (p63 Delta)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Immunohistochemistry (IHC), ELISA
克隆位点
14D5E8F12
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抗原表位
- AA 4-19
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原理
- Anti-p40 [14D5E8F12], Mouse IgG1, kappa
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特异性
- This antibody is specific for the p40 peptide of the human p63. P63 protein acts as a sequence specific DNA binding transcriptional activator or repressor. It is also involved in notch signaling by probably inducing JAG1 and JAG2 and plays a role in the regulation of epithelial morphogenesis. The p63 Molecule has a high degree of structural homology with p53 and has three similar functional domains: N-terminal transcription activation region, core DNA binding region, and C-terminal oligomerization region.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing mice with p40 peptide comprising amino acids 4-19 (LENNAQTQFSEPQYTN) of the p63 protein (Uniprot -Q9H3D4). The p40 peptide had a sulfhydryl group at its N-terminus and a carrier protein KLH to improve its immunogenicity.
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亚型
- IgG1 kappa
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anti-p40 (p63 Delta) (AA 5-17) antibody
适用: 人, Cow, 小鼠, 大鼠 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- This antibody is highly similar to commercially available rabbit antibody ZR8 in immunohistochemical staining of p40. This antibody does not stain lung adenocarcinoma but positively stains lung squamous cell carcinoma. This antibody can used for the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma via immunohistochemical staining. This binding specificity and affinity of this antibody was determined using ELISA. The original IgG1 antibody is reported to bind human p40 with an affinity constant of 5.99 X 10^9 M^(-1) (CN104447994).
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- p40 (p63 Delta)
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别名
- p40
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背景
- TP63, CUSP, Tumor protein 63, chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p73L, p40, p51, ZR8
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UniProt
- Q9H3D4
抗原
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