Recombinant PD-1 抗体 (AA 32-160)
Quick Overview for Recombinant PD-1 抗体 (AA 32-160) (ABIN7543294)
抗原
See all PD-1 (PDCD1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 32-160
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原理
- Anti-PD-1 [11F5C5], Rabbit IgG, kappa
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特异性
- This antibody binds the extracellular domain of the human PD-1. PD-1 is an immunosuppressive receptor having a molecular weight of 50 to 55 kD, a type 1 transmembrane glycoprotein belonging to immunoglobulin CD28 / CTLA-4 family members. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. It delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing BALB/c mice with recombinant human PD-1 protein comprising amino acids 32-160.
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亚型
- IgG kappa
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anti-Programmed Cell Death 1 (PDCD1) (AA 201-288) antibody
PDCD1 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8G5B12 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 3B3D9 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 3E12A10 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 1D6F6 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 1-288) antibodyPDCD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) antibodyPDCD1 适用: 人 IHC, ELISA, StM, Coat 宿主: 小鼠 Monoclonal PDCD1-2720 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 1-212) antibodyPDCD1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- This antibody is highly similar to the commercially available anti-PD-1 antibody NAT105. The binding specificity of this antibody towards human PD-1 was determined using ELISA. The original IgG2a antibody binds human PD_1 with an affinity constant of 7.13X10^9 M^(-1). This antibody is capable of detecting human PD-1 in a western blot assay. This antibody was used in the immunohistochemical staining of samples of T cell lymphomas and B cell lymphomas (CN109293775).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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别名
- PD-1
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背景
- CD279, PD1, PD 1, hPD-1, PDCD1, Programmed cell death protein 1, Programmed cell death 1, Protein PD-1, CGMCC NO.16209, NAT105
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UniProt
- Q15116
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途径
- Cancer Immune Checkpoints
抗原
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