Recombinant TIGIT 抗体
Quick Overview for Recombinant TIGIT 抗体 (ABIN7543291)
抗原
See all TIGIT 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-TIGIT [AET2010], Human IgG1, lambda
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特异性
- This antibody binds the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. It is an immune receptor present on some T cells and natural killer cells (NK). It binds the poliovirus receptor (PVR) with high affinity which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was isolated from a fully synthetic human single chain antibody phage display library by multiple rounds of bio panning against human TIGIT.
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亚型
- IgG1 lambda
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anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 21-234) antibody
TIGIT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 IHC, ELISA, FACS, Coat, StM 宿主: 小鼠 Monoclonal TIGIT-3017 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4C5B9 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-246) antibodyTIGIT 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal TIGIT-3106 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-227) antibodyTIGIT 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) antibodyTIGIT 适用: 小鼠 ELISA, FACS, BP 宿主: 兔 Chimeric 1B4 unconjugated Recombinant Antibody
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM178 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 12-142) antibodyTIGIT 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB55818 unconjugated
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应用备注
- The binding characterization of this antibody for TIGIT was done using ELISA. The IgG1 version of this antibody binds human TIGIT with a binding affinity of Kd= 3.74 nM. This antibody is also capable of blocking the binding of TIGIT to its ligand CD155. The binding of this antibody to membrane bound TIGIT was determined using flow cytometry. The anti-tumor activity of this antibody was tested against NK-92MI cells in vitro. It was also reported that AET 2010 exhibits enhanced anti-tumor activity in the CDX mouse model of NK-92MI cells (CN112679610).
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
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别名
- TIGIT
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背景
- VSTM3, VSIG9, WUCAM, T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3
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UniProt
- Q495A1
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途径
- Cancer Immune Checkpoints
抗原
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