Recombinant Mesothelin 抗体
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Quick Overview for Recombinant Mesothelin 抗体 (ABIN7543232)
抗原
See all Mesothelin (MSLN) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Mesothelin [MOR06626], Rabbit IgG, kappa
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特异性
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This antibody binds the human and murine mesothelin. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. Because of its limited expression in normal tissues and overexpression in tumors, mesothelin is a promising candidate for tumor-specific therapy.
Application Notes original Clone: The binding reactivity of the Fab version of this antibody towards human and murine mesothelin was done using ELISA. The Fab version of this antibody binds human and murine meosthelin with a binding affinity of Kd= 6.7 x 10-10 and Kd= 6.7 x 10-9 (US9023351). The IgG1 version of this antibody was used to detect mesothelin on NCI-H226 cells by flow cytometry (US9023351).
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交叉反应
- 小鼠
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产品特性
- This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was isolated from a synthetic phage display library (HuCAL®) after 3 rounds of panning against whole CHO-A9 and NCI-H226 cells expressing mesothelin.
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亚型
- IgG, kappa
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anti-Mesothelin (MSLN) (AA 273-407) antibody
MSLN 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal MSLN-2131 unconjugated
anti-Mesothelin (MSLN) (AA 101-200) antibodyMSLN 适用: 人 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mesothelin (MSLN) (AA 273-407) antibodyMSLN 适用: 人 IHC 宿主: 小鼠 Monoclonal MSLN-3384 unconjugated
anti-Mesothelin (MSLN) (AA 37-286) antibodyMSLN 适用: 人, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5C11A4 unconjugated
anti-Mesothelin (MSLN) (AA 37-286) antibodyMSLN 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4H12F8 unconjugated
anti-Mesothelin (MSLN) (AA 296-606) antibodyMSLN 适用: 人, 大鼠 WB, ELISA 宿主: 小鼠 Monoclonal 7E6A6 unconjugated
anti-Mesothelin (MSLN) (AA 37-598) antibodyMSLN 适用: 人 ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Mesothelin (MSLN) (AA 273-407) antibody (Biotin)MSLN 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal Biotin
anti-Mesothelin (MSLN) (AA 296-580) antibodyMSLN 适用: 人 ELISA, IHC, FACS 宿主: 兔 Monoclonal DM71 unconjugated
anti-Mesothelin (MSLN) antibodyMSLN 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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OriginalSpeciesName: Human
OriginalFormat: IgG1
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Mesothelin (MSLN)
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别名
- Mesothelin
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背景
- MSLN, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor
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UniProt
- Q13421
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途径
- EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
抗原
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